P
Pamela L. Mellon
Researcher at University of California, San Diego
Publications - 199
Citations - 14622
Pamela L. Mellon is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gonadotropin-releasing hormone & Transcription factor. The author has an hindex of 64, co-authored 196 publications receiving 13971 citations. Previous affiliations of Pamela L. Mellon include University of California, San Francisco & National Institutes of Health.
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Journal ArticleDOI
Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis
Pamela L. Mellon,Jolene J. Windle,Paul C. Goldsmith,Cheryl A. Padula,James L. Roberts,Richard I. Weiner +5 more
TL;DR: These immortalized cells will provide an invaluable model system for study of hypothalamic neurosecretory neurons that regulate reproduction and demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
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Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system
TL;DR: A rapid and simple method for studying the transcription of cloned eucaryotic genes is developed, which involves transfecting SV40-transformed monkey cell lines (COS cells) with derivatives of the plasmid pBR322 that contain the SV40 viral replication origin but lack regions necessary for viral transcription (SV-ORI vectors).
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Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice.
TL;DR: Targeted tumorigenesis in transgenic mice to anterior pituitary cells of the gonadotrope lineage is targeted to immortalize this specific endocrine cell while maintaining several highly differentiated functions unique to gonadotropes.
Journal ArticleDOI
Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer
TL;DR: It is shown by gene transfer studies that the same glucocorticoid receptor that activates gene expression can negatively regulate expression of the human glycoprotein hormone alpha-subunit gene.
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Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.
TL;DR: It is concluded that this novel element acts, perhaps through a specific trans-acting factor, in concert with a cAMP-responsive enhancer to confer tissue specificity to the alpha-subunit gene.