Satish A. Eraly

TL;DR: The results suggest that RST, Oat1, and Oat3 each contribute to urate handling, but, at least in mice, the bulk of reabsorption is mediated by a transporter(s) that remains to be identified.

TL;DR: A critical role for OAT1 is found in the functioning of the classical pathway, and the levels of ∼60 endogenous organic anions in the plasma and urine of wild-type and knock-out mice are determined, leading to identification of several compounds with significantly higher plasma concentrations and/or lower urinary concentrations in knock- out mice, suggesting the involvement of Oat1 in their renal secretion.

TL;DR: In this paper, the role of OAT1 in the PAH pathway was investigated in the context of other potentially functionally redundant transporters (e.g., OAT2, OAT3, and MRP1).

TL;DR: Both furosemide and bendroflumethiazide inhibited mOat1- and mOAT3-mediated uptake of a labeled tracer in Xenopus oocytes injected with cRNA, consistent with their being substrates for mouse OAT1 and OAT3.

TL;DR: The genomic sequencing of murine OAT1 and OAT3 and derivation of phylogenetic footprints by comparison to the human genome are reported, and it is found that pair-members have similar tissue distributions, suggesting that the pairing might exist to facilitate the co-regulation of the genes within each pair.