M
Mark A. van Buchem
Researcher at Leiden University
Publications - 69
Citations - 9696
Mark A. van Buchem is an academic researcher from Leiden University. The author has contributed to research in topics: Hyperintensity & Population. The author has an hindex of 37, co-authored 69 publications receiving 7671 citations. Previous affiliations of Mark A. van Buchem include Leiden University Medical Center.
Papers
More filters
Journal ArticleDOI
Frontal lobe structure and executive function in migraine patients
N Schmitz,Enrico B Arkink,Marieke Mulder,Katya Rubia,Faiza Admiraal-Behloul,Guus G. Schoonmann,Mark C. Kruit,Michel D. Ferrari,Mark A. van Buchem +8 more
TL;DR: Migraineurs showed decreased frontal and parietal lobe GM density and slower response time to task set-shifting and, the delayed response time correlated significantly with reduced GM density of the frontal lobes in migraineurs.
Journal ArticleDOI
Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease
Eve M. Dumas,Simon J.A. van den Bogaard,Margot E. Ruber,Ralf Reilmann,Julie C. Stout,Julie C. Stout,David Craufurd,Stephen Hicks,Christopher Kennard,Sarah J. Tabrizi,Mark A. van Buchem,Jeroen van der Grond,Raymund A.C. Roos +12 more
TL;DR: Disturbances in the white matter connections of the sensorimotor cortex can be demonstrated not only in manifest HD but also in premanifest gene carriers.
Journal ArticleDOI
Endogenous cortisol is associated with functional connectivity between the amygdala and medial prefrontal cortex
Ilya M. Veer,Ilya M. Veer,Nicole Y. L. Oei,Nicole Y. L. Oei,Philip Spinhoven,Mark A. van Buchem,Mark A. van Buchem,Bernet M. Elzinga,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts +9 more
TL;DR: The results corroborate previous findings from both animal and human studies, suggesting cortisol-mediated regulation of the amygdala by the mPFC and propose that through this feedback mechanism the stress response might be adjusted, pointing to the putative role of cortisol in modulating stress- and, more generally, emotional responses.
Journal ArticleDOI
Cortical Iron Reflects Severity of Alzheimer's Disease.
Sara van Duijn,Marjolein Bulk,Sjoerd G. van Duinen,Rob J.A. Nabuurs,Mark A. van Buchem,Louise van der Weerd,Remco Natté +6 more
TL;DR: In this article, the authors used formalin fixed paraffin embedded frontal cortex from 10 AD patients, 10 elder, 10 middle aged, and 10 young controls and visualized iron with a modified Perl's histochemical procedure.
Journal ArticleDOI
Practice effects in the brain: Changes in cerebral activation after working memory practice depend on task demands.
Dietsje Jolles,Meike J. Grol,Meike J. Grol,Mark A. van Buchem,Mark A. van Buchem,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts,Eveline A. Crone +7 more
TL;DR: It is demonstrated that practice was beneficial for both working memory maintenance and manipulation processes but that these processes were supported by different neural changes, which illustrate the importance of controlling for test-retest effects in training or intervention studies.