Mark A. van Buchem

TL;DR: MRI scans in cognitively healthy subjects with and without microtubule-associated protein Tau (MAPT) or progranulin (GRN) mutations were acquired to investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between Cognitively healthy carriers of pathogenic FTD mutations, and cognitivelyhealthy carriers at increased AD risk.

TL;DR: While higher glucose was associated with macro- Structural damage, impaired insulin action was associated more strongly with reduced micro-structural brain parenchymal homogeneity, and some insight is offered into the association between different parameters of glucose metabolism and brain aging.

TL;DR: It is demonstrated that Ser704Cys-genotype influences (para)hippocampal structure and functioning the dorsal PFC during executive planning, most prominently in unaffected controls, and results suggest that presence of psychopathology moderates Ser701Cys effects.

TL;DR: Many of the most important literature references relevant to neurophysiological investigations in clinical practice are reviewed and the prospects for future research are looked at.