M
Mark A. van Buchem
Researcher at Leiden University
Publications - 69
Citations - 9696
Mark A. van Buchem is an academic researcher from Leiden University. The author has contributed to research in topics: Hyperintensity & Population. The author has an hindex of 37, co-authored 69 publications receiving 7671 citations. Previous affiliations of Mark A. van Buchem include Leiden University Medical Center.
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Journal ArticleDOI
Pseudocontinuous Arterial Spin Labeling Reveals Dissociable Effects of Morphine and Alcohol on Regional Cerebral Blood Flow
Najmeh Khalili-Mahani,Najmeh Khalili-Mahani,Matthias J.P. van Osch,E. Baerends,E. Baerends,Roelof P. Soeter,Roelof P. Soeter,Marieke de Kam,Remco W. M. Zoethout,Albert Dahan,Mark A. van Buchem,Mark A. van Buchem,Joop M. A. van Gerven,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts +14 more
TL;DR: These findings suggest that PCASL is a promising tool for central nervous system drug research and suggest a widespread increase in absolute CBF because of both morphine and alcohol.
Journal ArticleDOI
Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain
Adriaan C.G.M. van Es,Jeroen van der Grond,V. Hester ten Dam,Anton J. M. de Craen,Gerard J. Blauw,Rudi G. J. Westendorp,Faiza Admiraal-Behloul,Mark A. van Buchem +7 more
TL;DR: It is concluded that, when evaluating tCBF alterations due to various pathologies, t CBF should in mL/100 mL/min instead of mL/Min, and changes or differences in WMH volume should be accounted for.
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Functional Connectivity Changes and Executive and Social Problems in Neurofibromatosis Type I
Marisa Loitfelder,Marisa Loitfelder,Stephan C. J. Huijbregts,Ilya M. Veer,Ilya M. Veer,Hanna S. Swaab,Mark A. van Buchem,Mark A. van Buchem,Reinhold Schmidt,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts +10 more
TL;DR: NF1 patients showed differences in functional connectivity between areas associated with cognitive and social functioning when compared to controls, and the fact that connectivity strengths in these networks were associated with worse cognitive, social, and behavioral outcomes, suggests a neuropathological basis for the widespread deficits observed in NF1.
Journal ArticleDOI
Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms.
Stephan C. J. Huijbregts,Marisa Loitfelder,Marisa Loitfelder,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts,Hanna Swaab,Berit M. Verbist,Berit M. Verbist,Enrico B Arkink,Mark A. van Buchem,Mark A. van Buchem,Ilya M. Veer,Ilya M. Veer +12 more
TL;DR: Widespread volumetric differences between patients and controls were found in cortical and subcortical brain regions and, in NF1 patients but not HC, larger volumes were associated with poorer behavior ratings.
Journal ArticleDOI
Practice effects in the developing brain: a pilot study.
Dietsje Jolles,Dietsje Jolles,Mark A. van Buchem,Mark A. van Buchem,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts,Eveline A. Crone +6 more
TL;DR: Preliminary findings argue against the hypothesis that certain brain structures cannot be engaged because of immaturity, and further examine flexibility in the developing brain, and establish what can and cannot be expected of children across school-aged development.