M
Mark A. van Buchem
Researcher at Leiden University
Publications - 69
Citations - 9696
Mark A. van Buchem is an academic researcher from Leiden University. The author has contributed to research in topics: Hyperintensity & Population. The author has an hindex of 37, co-authored 69 publications receiving 7671 citations. Previous affiliations of Mark A. van Buchem include Leiden University Medical Center.
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Journal ArticleDOI
Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults
Zsuzsika Sjoerds,Zsuzsika Sjoerds,Marie-José van Tol,Wim van den Brink,Nic J.A. van der Wee,Mark A. van Buchem,André Aleman,Brenda W.J.H. Penninx,Dick J. Veltman,Dick J. Veltman +9 more
TL;DR: It is suggested that GM abnormalities in the parahippocampal gyrus represent a persistent biological susceptibility for AD or related psychopathology and not neurotoxicity of alcohol or delayed brain maturation, similar to drinking and non-drinking FH+ adolescents.
Journal ArticleDOI
Diastolic Carotid Artery Wall Shear Stress Is Associated With Cerebral Infarcts and Periventricular White Matter Lesions
Henri J.M.M. Mutsaerts,Inge H. Palm-Meinders,Anton J. M. de Craen,Johan H. C. Reiber,Gerard J. Blauw,Mark A. van Buchem,Jeroen van der Grond,Frieke M.A. Box +7 more
TL;DR: This study is the first to the authors' knowledge to present a cross-sectional correlation between carotid artery WSS and cerebrovascular pathology such as PWML and CI in a large population, and shows that diastolic hemodynamics may be more important than systolic or mean hemodynamics.
Journal ArticleDOI
White Matter Lesion Progression Genome-Wide Search for Genetic Influences
Edith Hofer,Margherita Cavalieri,Joshua C. Bis,Charles DeCarli,Myriam Fornage,Sigurdur Sigurdsson,Velandai Srikanth,Stella Trompet,Benjamin F.J. Verhaaren,Christiane Wolf,Christiane Wolf,Qiong Yang,Hieab H.H. Adams,Philippe Amouyel,Alexa S. Beiser,Brendan M. Buckley,Michele L. Callisaya,Ganesh Chauhan,Ganesh Chauhan,Anton J. M. de Craen,Carole Dufouil,Cornelia M. van Duijn,Ian Ford,Paul Freudenberger,Rebecca F. Gottesman,Vilmundur Gudnason,Gerardo Heiss,Albert Hofman,Thomas Lumley,Oliver Martinez,Bernard Mazoyer,Chris Moran,Wiro J. Niessen,Wiro J. Niessen,Thanh G. Phan,Bruce M. Psaty,Bruce M. Psaty,Claudia L. Satizabal,Naveed Sattar,Sabrina Schilling,Sabrina Schilling,Dean Shibata,P. Eline Slagboom,Albert V. Smith,David J. Stott,Kent D. Taylor,Kent D. Taylor,Russell Thomson,Anna Maria Töglhofer,Christophe Tzourio,Mark A. van Buchem,Jing Wang,Rudi G. J. Westendorp,Rudi G. J. Westendorp,B. Gwen Windham,Meike W. Vernooij,Alex P. Zijdenbos,Richard Beare,Richard Beare,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,M. Arfan Ikram,J. Wouter Jukema,Lenore J. Launer,W. T. Longstreth,Thomas H. Mosley,Sudha Seshadri,Helena Schmidt,Reinhold Schmidt +69 more
TL;DR: Common genetic factors contribute little to the progression of age-related WML in middle-aged and older adults, and future research on determinants of WML progression should focus more on environmental, lifestyle, or host-related biological factors.
Journal ArticleDOI
Spatial heterogeneity of the relation between resting-state connectivity and blood flow: an important consideration for pharmacological studies.
Najmeh Khalili-Mahani,Najmeh Khalili-Mahani,Matthias J.P. van Osch,Matthias J.P. van Osch,Mark de Rooij,Christian F. Beckmann,Mark A. van Buchem,Mark A. van Buchem,Albert Dahan,Johannes M. van Gerven,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts +11 more
TL;DR: The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs, and is tested by examining the relation between CBF and resting‐state‐network consistency in a crossover placebo‐controlled study of morphine and alcohol.
Journal ArticleDOI
Changes in regional brain activation related to depressive state: a 2-year longitudinal functional mri study
Esther M. Opmeer,Rudie Kortekaas,Marie-José van Tol,Remco J. Renken,Liliana Ramona Demenescu,Saskia Woudstra,Gert J. Ter Horst,Mark A. van Buchem,Mark A. van Buchem,Nic J.A. van der Wee,Nic J.A. van der Wee,Dick J. Veltman,Dick J. Veltman,André Aleman,André Aleman +14 more
TL;DR: The natural course of brain activation in response to emotional faces in depression, indexed by functional magnetic resonance imaging (fMRI) scans preceding and following change in depressive state is investigated.