M
Mark Bathe
Researcher at Massachusetts Institute of Technology
Publications - 149
Citations - 7447
Mark Bathe is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: DNA origami & DNA nanotechnology. The author has an hindex of 40, co-authored 132 publications receiving 5850 citations. Previous affiliations of Mark Bathe include Ludwig Maximilian University of Munich & Broad Institute.
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A primer to scaffolded DNA origami
Carlos E. Castro,Fabian Kilchherr,Do-Nyun Kim,Enrique Lin Shiao,Tobias Wauer,Philipp Wortmann,Mark Bathe,Hendrik Dietz +7 more
TL;DR: A computational tool for predicting the structure of DNA Origami objects is introduced and information is provided on the conditions under which DNA origami objects can be expected to maintain their structure.
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Designer nanoscale DNA assemblies programmed from the top down.
TL;DR: This work presents a general solution to this problem that offers the ability for nonspecialists to design and synthesize nearly arbitrary DNA-based nanoparticles using only a simple surface-based representation of target 3D geometry to automatically generate the ssDNA needed to synthesize the object.
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Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures
TL;DR: This model represents an important advance in the quantitative understanding of DNA-based nanostructure shape and flexibility, and it is anticipated that this model will increase significantly the number and variety of synthetic nanostructures designed using nucleic acids.
Designer nanoscale DNA assemblies programmed from the top down
TL;DR: In this article, a top-down strategy was proposed to design nearly arbitrary DNA architectures autonomously based only on target shape, represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes.
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Actin-binding proteins sensitively mediate F-actin bundle stiffness.
TL;DR: This work measures the bending stiffness of F-actin bundles crosslinked by three ABPs that are ubiquitous in eukaryotes and observes distinct regimes of bundle bending stiffness that differ by orders of magnitude depending on ABP type, concentration and bundle size.