K
Kaiming Zhang
Researcher at Stanford University
Publications - 74
Citations - 2506
Kaiming Zhang is an academic researcher from Stanford University. The author has contributed to research in topics: RNA & Chemistry. The author has an hindex of 19, co-authored 55 publications receiving 1515 citations. Previous affiliations of Kaiming Zhang include Peking University & Baylor College of Medicine.
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Designer nanoscale DNA assemblies programmed from the top down.
TL;DR: This work presents a general solution to this problem that offers the ability for nonspecialists to design and synthesize nearly arbitrary DNA-based nanoparticles using only a simple surface-based representation of target 3D geometry to automatically generate the ssDNA needed to synthesize the object.
Designer nanoscale DNA assemblies programmed from the top down
TL;DR: In this article, a top-down strategy was proposed to design nearly arbitrary DNA architectures autonomously based only on target shape, represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes.
Journal ArticleDOI
Measurement of atom resolvability in cryo-EM maps with Q -scores
Grigore D. Pintilie,Kaiming Zhang,Zhaoming Su,Shanshan Li,Michael F. Schmid,Wah Chiu,Wah Chiu +6 more
TL;DR: Q -score analysis of multiple cryo-EM maps of the same proteins derived from different laboratories confirms the reproducibility of structural features from side chains down to water and ion atoms, and can be used at the atom, residue or macromolecule scale.
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A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice
Abigail E. Powell,Kaiming Zhang,Mrinmoy Sanyal,Shaogeng Tang,Payton A. Weidenbacher,Shanshan Li,Tho D. Pham,John E. Pak,Wah Chiu,Wah Chiu,Peter S. Kim +10 more
TL;DR: In this paper, the authors designed subunit vaccine candidates using selfassembling ferritin nanoparticles displaying one of two multimerized SARS-CoV-2 spikes: full-length ectodomain (S-Fer) or a C-terminal 70 amino acid deletion (SΔC-Fer).
Journal ArticleDOI
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
Kalli Kappel,Kaiming Zhang,Zhaoming Su,Zhaoming Su,Andrew M. Watkins,Wipapat Kladwang,Shanshan Li,Grigore D. Pintilie,Ved V Topkar,Ramya Rangan,Ivan N Zheludev,Joseph D. Yesselman,Joseph D. Yesselman,Wah Chiu,Wah Chiu,Rhiju Das +15 more
TL;DR: It is demonstrated that cryo-electron microscopy can routinely resolve maps of RNA-only systems and that these maps enable subnanometer-resolution coordinate estimation when complemented with multidimensional chemical mapping and Rosetta DRRAFTER computational modeling.