M
Mark C. Willingham
Researcher at Laboratory of Molecular Biology
Publications - 394
Citations - 37029
Mark C. Willingham is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Cell culture & Thyroid hormone receptor. The author has an hindex of 94, co-authored 394 publications receiving 36167 citations. Previous affiliations of Mark C. Willingham include Children's Memorial Hospital & Medical University of South Carolina.
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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
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Expression of Multidrug Resistance Gene in Human Cancers
Lori J. Goldstein,Hanan Galski,Antonio Tito Fojo,Mark C. Willingham,Shinn Lian Lai,Adi F. Gazdar,Robert Pirker,Alexander A. Green,William M. Crist,Garrett M. Brodeur,Michael M. Lieber,Jeffrey Cossman,Michael M. Gottesman,Ira Pastan +13 more
TL;DR: Evaluation of MDR1 gene expression may prove to be a valuable tool in the identification of individuals whose cancers are resistant to specific agents, and the information may be useful in designing or altering chemotherapeutic protocols in these patients.
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The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection
TL;DR: The results indicate that the Rous sarcoma virus LTR can direct synthesis of high levels of functional mRNA and has a wide expression range.
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Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
TL;DR: It is proposed that dansylcadaverine inhibits EGF internalization by preventing it from clustering in clathrin-coated pits.
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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: It is reported that MRK16 also detects P170 in the capillaries of some human brain samples, and MAb C219, a monoclonal antibody shown to react with P170, shows intense localization in selected skeletal muscle fibers and all cardiac muscle fibers in rat and human tissues.