M
Mark E. Gurney
Researcher at deCODE genetics
Publications - 147
Citations - 22658
Mark E. Gurney is an academic researcher from deCODE genetics. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 55, co-authored 140 publications receiving 21917 citations. Previous affiliations of Mark E. Gurney include Loyola University Medical Center & Northwestern University.
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Journal ArticleDOI
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Douglas R. Davies,Bjorn Mamat,Olafur T. Magnusson,Jeff Christensen,Magnus H. Haraldsson,Rama K. Mishra,Brian Pease,Erik C Hansen,Jasbir Singh,David E. Zembower,Hidong Kim,Alex S. Kiselyov,Alex B. Burgin,Mark E. Gurney,Lance Stewart +14 more
TL;DR: A novel fragment library termed fragments of life (FOL) for structure-based drug discovery including natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics is described and screened against leukotriene A4 hydrolase by X-ray crystallography.
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Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy
Matthew E.R. Butchbach,Jasbir Singh,Margrét Þorsteinsdóttir,Luciano Saieva,Elzbieta Slominski,John Thurmond,Thorkell Andresson,Jun Zhang,Jonathan D. Edwards,Louise R. Simard,Livio Pellizzoni,Jill Jarecki,Arthur H.M. Burghes,Mark E. Gurney +13 more
TL;DR: Oral administration of C5-quinazoline derivative D156844 increases SMN expression in neonatal mouse neural tissues, delays motor neuron loss at PND11 and ameliorates the motor phenotype of SMNDelta7 SMA mice.
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Functional interaction and partial homology between human immunodeficiency virus and neuroleukin
TL;DR: The inhibition by HIV-1 of neuron growth in the presence of NLK was found to be due to the gp120 envelope glycoprotein, and regions of sequence homology between gp120 and NLK may account for this inhibitory property of gp120.
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Suppression of sprouting at the neuromuscular junction by immune sera
TL;DR: Rabbit antisera against a 56,000 (56K)-molecular weight protein secreted by denervated rat muscle suppress botulinum toxin-induced terminal sprouting in the mouse gluteus muscle, detecting an immune response against this protein in patients with amyotrophic lateral sclerosis.
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Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics.
TL;DR: It is proposed that DCFH oxidation to DCF is a sensitive index for measuring the peroxidase activity of SOD1 and familial amyotrophic lateral sclerosis S OD1 mutants and that the carbonate radical anion (CO⨪3) is responsible for oxidation of DCFH to DCf in the SOD 1/H2O2/bicarbonate system.