M
Mark J. Roef
Publications - 11
Citations - 240
Mark J. Roef is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 6 publications receiving 148 citations.
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Journal ArticleDOI
Detection of residual disease after neoadjuvant chemoradiotherapy for oesophageal cancer (preSANO): a prospective multicentre, diagnostic cohort study.
Bo Jan Noordman,Manon C.W. Spaander,Roelf Valkema,Bas P. L. Wijnhoven,Mark I. van Berge Henegouwen,Joel Shapiro,Katharina Biermann,Ate van der Gaast,Richard van Hillegersberg,Maarten C.C.M. Hulshof,Kausilia K. Krishnadath,Sjoerd M. Lagarde,Grard A. P. Nieuwenhuijzen,Liekele E. Oostenbrug,Peter D. Siersema,Peter D. Siersema,Erik J. Schoon,Meindert N. Sosef,Ewout W. Steyerberg,Ewout W. Steyerberg,J. Jan B. van Lanschot,Michael Doukas,Nanda C. Krak,Jan-Werner Poley,Caroline M. van Rij,Jaques Jghm Bergman,Suzanne S. Gisbertz,Hanneke W. M. van Laarhoven,Sybren L. Meijer,Lucas Goense,Nadia Haj Mohammad,Monique G.G. Hobbelink,G. Johan A. Offerhaus,Frank P. Vleggaar,Wouter L. Curvers,Geert-Jan Creemers,Mark J. Roef,Maurice J.C. van der Sangen,Jeroen Buijsen,Robert G. Riedl,Wendy M. J. Schreurs,Fabiënne A. R. M. Warmerdam,Mjr Janssen,Chella Van Der Post,Sandra A Radema,Camiel Rosman,H.J.T. Rutten +46 more
TL;DR: The correlation between clinical response during clinical response evaluations and the final pathological response in resection specimens was shown, as shown by the proportion of tumour regression grade (TRG) 3 or 4 residual tumours that was missed duringclinical response evaluations.
Journal ArticleDOI
Active Surveillance Versus Immediate Surgery in Clinically Complete Responders After Neoadjuvant Chemoradiotherapy for Esophageal Cancer: A Multicenter Propensity Matched Study
Berend J van der Wilk,Bo Jan Noordman,Lisanne K A Neijenhuis,Daan Nieboer,Grard A. P. Nieuwenhuijzen,Meindert N. Sosef,Mark I. van Berge Henegouwen,Sjoerd M. Lagarde,Manon C.W. Spaander,Roelf Valkema,Katharina Biermann,Bas P. L. Wijnhoven,Ate van der Gaast,J. Jan B. van Lanschot,Michael Doukas,Suzan Nikkessen,Misha D. P. Luyer,Erik J. Schoon,Mark J. Roef,Ineke van Lijnschoten,Liekele E. Oostenbrug,Robert G. Riedl,Suzanne S. Gisbertz,Kausilia K. Krishnadath,Roel J. Bennink,Sybren L. Meijer +25 more
TL;DR: In this retrospective study, OS and PFS in patients with cCR undergoing active surveillance or immediate surgery were not significantly different and active surveillance with postponed surgery for recurrent disease was not associated with a higher distant dissemination rate or more severe adverse postoperative outcomes.
Journal ArticleDOI
Improved Outcomes for Responders After Treatment with Induction Chemotherapy and Chemo(re)irradiation for Locally Recurrent Rectal Cancer.
E.L.K. Voogt,D. van Zoggel,Miranda Kusters,G.A.P. Nieuwenhuijzen,J.G. Bloemen,H.M.U. Peulen,G.J.M. Creemers,G. van Lijnschoten,Joost Nederend,Mark J. Roef,Jacobus W. A. Burger,H.J.T. Rutten +11 more
TL;DR: Induction chemotherapy in addition to neoadjuvant chemo(re)irradiation is a promising treatment strategy for patients with LRRC with high pathologic response rates that translate into improved oncological outcomes, especially when an R0 resection has been achieved.
Journal ArticleDOI
Surveillance of Clinically Complete Responders Using Serial 18F-FDG PET/CT Scans in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy.
Maria J. Valkema,Berend J van der Wilk,Ben M Eyck,Bas P. L. Wijnhoven,Manon C.W. Spaander,Michail Doukas,Sjoerd M. Lagarde,Wendy M. J. Schreurs,Mark J. Roef,J. Jan B. van Lanschot,Roelf Valkema +10 more
TL;DR: Serial 18F-FDG PET/CT scans for detecting local recurrence in patients beyond 3 mo after nCRT might be a useful tool for detecting tumor recurrence during active surveillance, suggesting that radiation-induced esophagitis had mostly resolved by that time.
Journal ArticleDOI
Metabolic positron emission tomography/CT response after induction chemotherapy and chemo(re)irradiation is associated with higher negative resection margin rate in patients with locally recurrent rectal cancer.
Desley M. G. I. van Zoggel,E.L.K. Voogt,Ineke van Lijnschoten,J. S. Cnossen,Geert-Jan Creemers,Joost Nederend,J.G. Bloemen,Grard A. P. Nieuwenhuijzen,Pim Burger,Sabine G. G. F. Lardenoije,Harm J. T. Rutten,Mark J. Roef +11 more
TL;DR: In this article, the correlation between the PET/CT response and final histopathological outcomes was analyzed, and the overall accuracy between PET score and pathological TRG was 45%, and the positive predictive value for CMR was 63%.