Mark Peterson

TL;DR: It is shown that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established mouse models and human tissue.

TL;DR: The goal of this article is to put into perspective the current applications, opportunities, and challenges associated with synthetic macrocycles in drug discovery.

TL;DR: It is determined that genes encoding IPF-associated ECM proteins are targets for miR-29, which was downregulated in fibroblasts grown on IPf-derived ECM, and baseline expression of ECM targets could be restored by overexpression of miR -29.

TL;DR: It is found that breast carcinoma cells harbor increases in the eif4F constituent eIF4GI and hyperphosphorylation of 4E-BP1 which are two alterations that activate eIF2F assembly, which is an essential component of the malignant phenotype in breast carcinomas.

TL;DR: Results provide direct evidence for defective negative regulation of the proliferative pathway in IPF fibroblasts and support the theory that the pathogenesis of IPF involves an intrinsic fibroblast defect.