scispace - formally typeset
M

Mark R. Hardy

Researcher at Johns Hopkins University

Publications -  21
Citations -  2507

Mark R. Hardy is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Oligosaccharide & Ion chromatography. The author has an hindex of 18, co-authored 21 publications receiving 2469 citations. Previous affiliations of Mark R. Hardy include ImmunoGen, Inc. & Genetics Institute, Inc..

Papers
More filters
Journal ArticleDOI

Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection.

Mark R. Hardy, +2 more
- 01 Apr 1988 - 
TL;DR: The method of anion exchange chromatography followed by pulsed amperometric detection with AE-PAD has been applied to the compositional analysis of glycoconjugates and approximately one less residue of Man than predicted was determined.
Journal ArticleDOI

Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.

Yuan C. Lee, +6 more
- 10 Jan 1983 - 
TL;DR: It was found that the number of Gal residues/cluster and their branching mode are major determinants of binding affinity of ligands to the hepatic lectin on the surface of hepatocytes.
Journal ArticleDOI

Separation of positional isomers of oligosaccharides and glycopeptides by high-performance anion-exchange chromatography with pulsed amperometric detection.

Mark R. Hardy, +1 more
- 01 May 1988 - 
TL;DR: High-performance anion-exchange (HPAE) chromatography under alkaline conditions (pH congruent to 13) has been found to efficiently separate neutral oligosaccharides (triose to undecaose) according to molecular size, sugar composition, and linkage of monosACcharide units.
Journal ArticleDOI

High-performance anion-exchange chromatography of oligosaccharides using pellicular resins and pulsed amperometric detection.

R.Reid Townsend, +3 more
- 01 Nov 1988 - 
TL;DR: High-performance liquid chromatography using pellicular quaternary amine-bonded resins was used to separate a variety of neutral, sialylated, and phosphorylated oligosaccharide mixtures using electrochemical response, and complete separation of the parent neutral structures was obtained.
Journal ArticleDOI

Separation of branched sialylated oligosaccharides using high-pH anion-exchange chromatography with pulsed amperometric detection.

R.Reid Townsend, +4 more
- 01 Oct 1989 - 
TL;DR: Ten characterized sialylated oligosaccharides from bovine fetuin were chromatographed using high-performance anion-exchange chromatography with pulsed amperometric detection and the relative molar electrochemical responses for di, tri, tetra, and pentasialylation oligosACcharides were found to be similar.