M
Mark T. W. Ebbert
Researcher at Mayo Clinic
Publications - 63
Citations - 4367
Mark T. W. Ebbert is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Population & Breast cancer. The author has an hindex of 23, co-authored 55 publications receiving 3620 citations. Previous affiliations of Mark T. W. Ebbert include Brigham Young University & ARUP Laboratories.
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Journal ArticleDOI
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
Yoko S. DeRose,Guoying Wang,Yi Chun Lin,Philip S. Bernard,Saundra S. Buys,Mark T. W. Ebbert,Rachel E. Factor,Cindy B. Matsen,Brett Milash,Edward W. Nelson,Leigh Neumayer,R. Lor Randall,Inge J. Stijleman,Bryan E. Welm,Alana L. Welm +14 more
TL;DR: It is reported that tumor engraftment is a prognostic indicator of disease outcome for women with newly diagnosed breast cancer and orthotopic breast tumor grafting is a step toward individualized models for tumor growth, metastasis and prognosis.
Journal ArticleDOI
A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer
Torsten O. Nielsen,Joel S. Parker,Samuel Leung,K. David Voduc,Mark T. W. Ebbert,Tammi L. Vickery,Sherri R. Davies,Jacqueline E. Snider,Inge J. Stijleman,Jerry S. Reed,Maggie C.U. Cheang,Maggie C.U. Cheang,Elaine R. Mardis,Charles M. Perou,Philip S. Bernard,Matthew J. Ellis +15 more
TL;DR: The PAM50 gene expression test for intrinsic biological subtype can be applied to large series of formalin-fixed, paraffin-embedded breast cancers, and gives more prognostic information than clinical factors and IHC using standard cut points.
Journal ArticleDOI
Genetics of Alzheimer’s Disease
TL;DR: The known genetics of early- and late-onset Alzheimer's disease are reviewed, including APOE, which is a complex disorder with environmental and genetic components leading to disease.
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PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
Roy R. L. Bastien,Álvaro Rodríguez-Lescure,Mark T. W. Ebbert,Aleix Prat,Aleix Prat,Blanca Munárriz,Leslie R. Rowe,Patricia Miller,Manuel Ruiz-Borrego,Daniel Anderson,Bradley W. Lyons,Isabel Alvarez,Tracy Dowell,David Wall,Miguel Ángel Seguí,Lee Barley,Kenneth M. Boucher,Emilio Alba,Lisa Pappas,Carole Davis,Ignacio Aranda,Christiane Fauron,Inge J. Stijleman,José Palacios,Antonio Antón,Eva Carrasco,Rosalía Caballero,Matthew J. Ellis,Torsten O. Nielsen,Charles M. Perou,Mark E. Astill,Philip S. Bernard,Philip S. Bernard,Miguel Martin +33 more
TL;DR: The standard immunohistochemical panel for breast cancer (ER, PR, and HER2) does not adequately identify the PAM50 gene expression subtypes and single gene scoring for ESR1, PGR, and ERBB2 was more prognostic than the corresponding IHC markers as shown in a multivariate analysis.
Journal ArticleDOI
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Yong Jie Zhang,Tania F. Gendron,Mark T. W. Ebbert,Aliesha D. O’Raw,Mei Yue,Karen Jansen-West,Xu Zhang,Mercedes Prudencio,Jeannie Chew,Casey Cook,Lillian M. Daughrity,Jimei Tong,Yuping Song,Sarah R. Pickles,Monica Castanedes-Casey,Aishe Kurti,Rosa Rademakers,Bjorn Oskarsson,Dennis W. Dickson,Wenqian Hu,Aaron D. Gitler,John D. Fryer,Leonard Petrucelli +22 more
TL;DR: The data suggest that poly(GR) contributes to c9FTD/ALS by impairing protein translation and stress granule dynamics, consequently causing chronic cellular stress and preventing cells from mounting an effective stress response.