J
John D. Fryer
Researcher at Mayo Clinic
Publications - 113
Citations - 9904
John D. Fryer is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Apolipoprotein E & Neurodegeneration. The author has an hindex of 52, co-authored 103 publications receiving 7833 citations. Previous affiliations of John D. Fryer include Baylor College of Medicine & Washington University in St. Louis.
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Journal ArticleDOI
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
Ian R. A. Mackenzie,Alexandra M. Nicholson,Mohona Sarkar,James Messing,Maria D. Purice,Cyril Pottier,Kavya Annu,Matt Baker,Ralph B. Perkerson,Aishe Kurti,Billie J. Matchett,Tanja Mittag,Jamshid Temirov,Ging-Yuek Robin Hsiung,Charles Krieger,Charles Krieger,Melissa E. Murray,Masato Kato,John D. Fryer,Leonard Petrucelli,Lorne Zinman,Sandra Weintraub,M.-Marsel Mesulam,Julia Keith,Sasha Zivkovic,Veronica Hirsch-Reinshagen,Raymond P. Roos,Stephan Züchner,Neill R. Graff-Radford,Ronald C. Petersen,Richard J. Caselli,Zbigniew K. Wszolek,Elizabeth Finger,Carol F. Lippa,Carol F. Lippa,David Lacomis,Heather Stewart,Dennis W. Dickson,Hong Joo Kim,Ekaterina Rogaeva,Eileen H. Bigio,Kevin B. Boylan,J. Paul Taylor,Rosa Rademakers +43 more
TL;DR: The identification of TIA1 mutations in ALS/FTD reinforces the importance of RNA metabolism and SG dynamics in ALS-FTD pathogenesis.
Journal ArticleDOI
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
Suzanne E. Wahrle,Hong Jiang,Maia Parsadanian,Justin Legleiter,Xianlin Han,John D. Fryer,Tomasz Kowalewski,David M. Holtzman +7 more
TL;DR: It is found that Abca1-/- mice have greatly decreased apoE levels in both the cortex (80% reduction) and the CSF (98% reduction), demonstrating that ABCA1 plays a critical role in CNS apOE metabolism.
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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi,Chia Chen Liu,Meghan M. Painter,Xiao Fen Chen,Christophe Verbeeck,Honghua Zheng,Xia Li,Rosa Rademakers,Silvia S. Kang,Huaxi Xu,Steven G. Younkin,Pritam Das,John D. Fryer,Guojun Bu,Guojun Bu +14 more
TL;DR: It is demonstrated that apoE-TREM2 interaction in microglia plays critical roles in modulating phagocytosis of apo E-bound apoptotic neurons and establish a critical link between two proteins whose genes are strongly linked to the risk for AD.
Journal ArticleDOI
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
Jeannie Chew,Tania F. Gendron,Mercedes Prudencio,Hiroki Sasaguri,Yong Jie Zhang,Monica Castanedes-Casey,Chris W. Lee,Karen Jansen-West,Aishe Kurti,Melissa E. Murray,Kevin F. Bieniek,Peter O. Bauer,Ena C. Whitelaw,Linda Rousseau,Jeannette N. Stankowski,Caroline Stetler,Lillian M. Daughrity,Emilie A. Perkerson,Pamela Desaro,Amelia Johnston,Karen Overstreet,Dieter Edbauer,Rosa Rademakers,Kevin B. Boylan,Dennis W. Dickson,John D. Fryer,Leonard Petrucelli +26 more
TL;DR: A mouse model that mimics both neuropathological and clinical phenotypes of c9FTD/ALS is described, including hyperactivity, anxiety, antisocial behavior, and motor deficits.
Journal ArticleDOI
ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology
Yung C. Lam,Aaron B. Bowman,Paymaan Jafar-Nejad,Janghoo Lim,Ronald Richman,John D. Fryer,Eric D. Hyun,Lisa A. Duvick,Harry T. Orr,Juan Botas,Huda Y. Zoghbi +10 more
TL;DR: In this paper, the authors examined soluble protein complexes from mouse cerebellum and found that the majority of wild-type and expanded ATXN1 assembles into large stable complexes containing the transcriptional repressor Capicua.