Casey Cook

TL;DR: It is reported that the ectopic expression of a ≈25-kDa TDP-43 fragment corresponding to the C-terminal truncation product of caspase-cleaved T DP-43 leads to the formation of toxic, insoluble, and ubiquitin- and phospho-positive cytoplasmic inclusions within cells.

TL;DR: It is shown that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space.

TL;DR: Reduced AV-1451 binding in neuritic pathology compared to neurofibrillary tangles suggests that the maturity of tau pathology may affect AV- fourteen51 binding and suggests complexity in AV- 1451 binding.

TL;DR: Cryo-electron microscopy is used to determine the structures of tau filaments from corticobasal degeneration (CBD) human brain tissue and proposes a structure-based model in which cross-talk between PTMs influences tau filament structure, contributing to the structural diversity of tauopathy strains.

TL;DR: It is shown that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional integrity and raises the possibility that NPC dysfunction contributes to tau-induced neurotoxicity in AD and tauopathies.