M
Mark Tilgner
Researcher at Wadsworth Center
Publications - 14
Citations - 1670
Mark Tilgner is an academic researcher from Wadsworth Center. The author has contributed to research in topics: Viral replication & Replicon. The author has an hindex of 14, co-authored 14 publications receiving 1601 citations. Previous affiliations of Mark Tilgner include State University of New York System & New York State Department of Health.
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Journal ArticleDOI
West Nile Virus 5′-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2′-O Methylations by Nonstructural Protein 5
Debashish Ray,Aaloki Shah,Mark Tilgner,Yi Guo,Yiwei Zhao,Hongping Dong,Tia S. Deas,Yangsheng Zhou,Hongmin Li,Hongmin Li,Pei Yong Shi,Pei Yong Shi +11 more
TL;DR: A critical role for the flavivirus MTase in viral reproduction is demonstrated and this domain is underscore this domain as a potential target for antiviral therapy.
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Infectious cDNA Clone of the Epidemic West Nile Virus from New York City
Pei Yong Shi,Pei Yong Shi,Mark Tilgner,Michael K. Lo,Kim A. Kent,Kristen A. Bernard,Kristen A. Bernard +6 more
TL;DR: The stable infectious cDNA clone of the epidemic lineage I strain of West Nile virus will provide a valuable experimental system to study the pathogenesis and replication of WNV.
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Inhibition of Flavivirus Infections by Antisense Oligomers Specifically Suppressing Viral Translation and RNA Replication
Tia S. Deas,Iwona Binduga-Gajewska,Mark Tilgner,Ping Ren,David A. Stein,Hong M. Moulton,Patrick L. Iversen,Elizabeth B. Kauffman,Laura D. Kramer,Laura D. Kramer,Pei Yong Shi,Pei Yong Shi +11 more
TL;DR: The results suggest that antisense PMO-mediated blocking of cis-acting elements of flavivirus genomes can potentially be developed into an anti-flavivirus therapy.
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Functional Analysis of Mosquito-Borne Flavivirus Conserved Sequence Elements within 3′ Untranslated Region of West Nile Virus by Use of a Reporting Replicon That Differentiates between Viral Translation and RNA Replication
TL;DR: It is demonstrated that genome cyclization through the 5′CS-CS1 interaction is essential for WNV RNA replication, whereas CS2, RCS2, CS3, and RCS3 facilitate, but are dispensable for, WNV replication.
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Construction and characterization of subgenomic replicons of New York strain of West Nile virus.
TL;DR: It is suggested that WNV replicons may serve as a noncytopathic RNA virus expression system and should provide a valuable tool to study WNV replication.