H
Hongmin Li
Researcher at New York State Department of Health
Publications - 102
Citations - 5468
Hongmin Li is an academic researcher from New York State Department of Health. The author has contributed to research in topics: T-cell receptor & Major histocompatibility complex. The author has an hindex of 36, co-authored 94 publications receiving 4738 citations. Previous affiliations of Hongmin Li include University of Arizona & University at Albany, SUNY.
Papers
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Journal ArticleDOI
Structure and function of flavivirus NS5 methyltransferase.
Yangsheng Zhou,Debashish Ray,Yiwei Zhao,Hongping Dong,Suping Ren,Suping Ren,Zhong Li,Yi Guo,Kristen A. Bernard,Kristen A. Bernard,Pei Yong Shi,Pei Yong Shi,Hongmin Li,Hongmin Li +13 more
TL;DR: The results demonstrate that the N-7 methylation activity is essential for the WNV life cycle and, thus, methyltransferase represents a novel target for flavivirus therapy.
Journal ArticleDOI
West Nile Virus 5′-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2′-O Methylations by Nonstructural Protein 5
Debashish Ray,Aaloki Shah,Mark Tilgner,Yi Guo,Yiwei Zhao,Hongping Dong,Tia S. Deas,Yangsheng Zhou,Hongmin Li,Hongmin Li,Pei Yong Shi,Pei Yong Shi +11 more
TL;DR: A critical role for the flavivirus MTase in viral reproduction is demonstrated and this domain is underscore this domain as a potential target for antiviral therapy.
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The structural basis of T cell activation by superantigens.
TL;DR: In this paper, the three-dimensional structure of bacterial superantigens and their complexes with MHC class II molecules and the TCRfl chain was studied. And the crystal structures also provided insights into the basis for the specificity of different SAGs for particular TCR fl chains, and for the observed influence of TCRfi chain on SAG reactivity.
Journal ArticleDOI
Crystal structure of a T-cell receptor β-chain complexed with a superantigen
Barry A. Fields,Emilio L. Malchiodi,Emilio L. Malchiodi,Hongmin Li,Xavier Ysern,Cynthia V. Stauffacher,Patrick M. Schlievert,Klaus Karjalainen,Roy A. Mariuzza +8 more
TL;DR: The crystal structures of the β-chain of a TCR complexed with the Staphylococcus aureus enterotoxins C2 and C3 (SEC2, SEC3) are reported, revealing that the SAg acts as a wedge between the T CR and MHC to displace the antigenic peptide away from the TCR combining site.
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Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.
TL;DR: A brief review of the broad antiviral activity of niclosamide is summarized and its potential clinical use in the treatment of COVID-19 is highlighted.