M
Michael K. Lo
Researcher at Centers for Disease Control and Prevention
Publications - 62
Citations - 4888
Michael K. Lo is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Virus & Ebola virus. The author has an hindex of 29, co-authored 58 publications receiving 3941 citations. Previous affiliations of Michael K. Lo include New York State Department of Health & Wadsworth Center.
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Journal ArticleDOI
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren,Robert Jordan,Michael K. Lo,Adrian S. Ray,Richard L. Mackman,Veronica Soloveva,Dustin Siegel,Michel Perron,Roy Bannister,Hui Hon Chung,Nate Larson,Robert G. Strickley,Jay Wells,Kelly S. Stuthman,Sean A. Van Tongeren,Nicole L. Garza,Ginger Donnelly,Amy C. Shurtleff,Cary Retterer,Dima N. Gharaibeh,Rouzbeh Zamani,Tara Kenny,Brett P. Eaton,Elizabeth C. Grimes,Lisa S. Welch,Laura Gomba,Catherine L. Wilhelmsen,Donald K. Nichols,Jonathan E. Nuss,Elyse R. Nagle,Jeffrey R. Kugelman,Gustavo Palacios,Edward Doerffler,Sean Neville,Ernest Carra,Michael O. Clarke,Lijun Zhang,Willard Lew,Bruce Ross,Queenie Wang,Kwon Soo Chun,Lydia Wolfe,Darius Babusis,Yeojin Park,Kirsten M. Stray,Iva Trancheva,Joy Y. Feng,Ona Barauskas,Yili Xu,Pamela Wong,Molly R. Braun,Mike Flint,Laura K. McMullan,Shan Shan Chen,Rachel Fearns,S. Swaminathan,Douglas L. Mayers,Christina F. Spiropoulou,William A. Lee,Stuart T. Nichol,Tomas Cihlar,Sina Bavari +61 more
TL;DR: These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates, and the broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenavirus, and coronavirus suggests the potential for wider medical use.
Journal ArticleDOI
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel,Hui Hon Chung,Edward Doerffler,Michael O'neil Hanrahan Clarke,Kwon Soo Chun,Lijun Zhang,Sean Neville,Ernest Carra,Willard Lew,Bruce Ross,Queenie Wang,Lydia Wolfe,Robert Jordan,Veronica Soloveva,John E. Knox,Jason K. Perry,Michel Perron,Kirsten M. Stray,Ona Barauskas,Joy Y. Feng,Yili Xu,Gary Lee,Arnold L. Rheingold,Adrian S. Ray,Roy Bannister,Robert G. Strickley,S. Swaminathan,William A. Lee,Sina Bavari,Tomas Cihlar,Michael K. Lo,Travis K. Warren,Richard L. Mackman +32 more
TL;DR: A robust diastereoselective synthesis provided sufficient quantities of 4b to enable preclinical efficacy in a non-human-primate EBOV challenge model and structure activity relationships established that the 1′-CN group and C-linked nucleobase were critical for optimal anti-EBOV potency and selectivity against host polymerases.
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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.
Michael K. Lo,Robert Jordan,Aaron Arvey,Jawahar Sudhamsu,Punya Shrivastava-Ranjan,Anne L. Hotard,Mike Flint,Laura K. McMullan,Dustin Siegel,Michael O. Clarke,Richard L. Mackman,Hui Hon Chung,Michel Perron,Adrian S. Ray,Tomas Cihlar,Stuart T. Nichol,Christina F. Spiropoulou +16 more
TL;DR: The antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families are reported, providing evidence to support new indications for this compound against human viruses of significant public health concern.
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Infectious cDNA Clone of the Epidemic West Nile Virus from New York City
Pei Yong Shi,Pei Yong Shi,Mark Tilgner,Michael K. Lo,Kim A. Kent,Kristen A. Bernard,Kristen A. Bernard +6 more
TL;DR: The stable infectious cDNA clone of the epidemic lineage I strain of West Nile virus will provide a valuable experimental system to study the pathogenesis and replication of WNV.
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Date palm sap linked to nipah virus outbreak in bangladesh, 2008
Muhammad Aziz Rahman,Mohammad Jahangir Hossain,Sharmin Sultana,Nusrat Homaira,Salah Uddin Khan,Mahmudur Rahman,Emily S. Gurley,Pierre E. Rollin,Michael K. Lo,James A. Comer,Luis Lowe,Paul A. Rota,Thomas G. Ksiazek,Thomas G. Ksiazek,Eben Kenah,Yushuf Sharker,Stephen P. Luby,Stephen P. Luby +17 more
TL;DR: This is the second Nipah outbreak in Bangladesh where date palm sap has been implicated as the vehicle of transmission and case-patients reported no history of physical contact with bats.