Mark Van Oene

TL;DR: It is reported here that two variants in the organic cation transporter cluster at 5q31 (a missense substitution in SLC22A4 and a G→C transversion in the SLC 22A5 promoter) form a haplotype associated with susceptibility to Crohn disease.

TL;DR: The results indicate that genetic polymorphisms affecting knee OA vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, FRZB, and COL2A1 in Caucasians.

TL;DR: It is found that genes previously identified by their association with subclinical features of knee OA or progression were also associated with clinical knees OA, and these genetic associations may identify individuals at a particularly high risk of developing knee Oa.

TL;DR: The data reveal a lack of association between this variant and Crohn's disease, suggesting that the PTPN22 1858T allele is a risk allele for multiple, but not all, autoimmune diseases.

TL;DR: The association of the SLC22A -TC haplotype and CARD15 alleles with ileal disease suggests that these variants have biologically intertwined effects in the pathogenesis of CD.