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Xiangjun Gu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 39
Citations - 4151
Xiangjun Gu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Genotype. The author has an hindex of 20, co-authored 34 publications receiving 3972 citations. Previous affiliations of Xiangjun Gu include Baylor College of Medicine.
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Journal ArticleDOI
Functional variants of OCTN cation transporter genes are associated with Crohn disease.
Vanya Peltekova,Richard F. Wintle,Laurence A. Rubin,Laurence A. Rubin,Christopher I. Amos,Qiqing Huang,Xiangjun Gu,Bill Newman,Mark Van Oene,David W. Cescon,Gordon R. Greenberg,Anne M. Griffiths,Peter St George-Hyslop,Katherine A. Siminovitch +13 more
TL;DR: It is reported here that two variants in the organic cation transporter cluster at 5q31 (a missense substitution in SLC22A4 and a G→C transversion in the SLC 22A5 promoter) form a haplotype associated with susceptibility to Crohn disease.
Journal ArticleDOI
Genome-wide association study identifies five susceptibility loci for glioma
Sanjay Shete,Fay J. Hosking,Lindsay B. Robertson,Sara E. Dobbins,Marc Sanson,Beatrice Malmer,Matthias Simon,Yannick Marie,Blandine Boisselier,Jean Yves Delattre,Khê Hoang-Xuan,Soufiane El Hallani,Ahmed Idbaih,Diana Zelenika,Ulrika Andersson,Roger Henriksson,A. Tommy Bergenheim,Maria Feychting,Stefan Lönn,Anders Ahlbom,Johannes Schramm,Michael Linnebank,Kari Hemminki,Rajesh Kumar,S. J. Hepworth,Amy Price,Georgina Armstrong,Yanhong Liu,Xiangjun Gu,Robert Yu,Ching C. Lau,Minouk J. Schoemaker,Kenneth Muir,Anthony J. Swerdlow,Mark Lathrop,Melissa L. Bondy,Richard S. Houlston +36 more
TL;DR: Meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs shows that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
Journal ArticleDOI
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
Gideon M. Hirschfield,Xiangdong Liu,Chun Xu,Yue Lu,Gang Xie,Yan Lu,Xiangjun Gu,Erin Walker,Kaiyan Jing,Brian D. Juran,Andrew Mason,Robert P. Myers,Kevork M. Peltekian,Cameron N. Ghent,Catalina Coltescu,Elizabeth J. Atkinson,Elizabeth J. Atkinson,E. Jenny Heathcote,Konstantinos N. Lazaridis,Christopher I. Amos,Katherine A. Siminovitch +20 more
TL;DR: Genomewide association data show significant associations between primary biliary cirrhosis and common genetic variants at the HLA class II, IL12A, and IL12RB2 loci and suggest that the interleukin-12 immunoregulatory signaling axis is relevant to the pathophysiology ofPrimary biliary Cirrhosis.
Journal ArticleDOI
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Yufei Wang,Peter Broderick,Emily L. Webb,Xifeng Wu,Jayaram Vijayakrishnan,Athena Matakidou,Mobshra Qureshi,Qiong Dong,Xiangjun Gu,Wei Vivien Chen,Margaret R. Spitz,Timothy Eisen,Christopher I. Amos,Richard S. Houlston +13 more
TL;DR: A genome-wide association study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls confirmed the most significant association was attained at 15q25.1 and identified two newly associated risk loci mapping to 6p21.33 and 5p15.33.
Journal Article
Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk.
Margaret R. Spitz,Cherie M. Duphorne,Michelle A. Detry,Patricia C. Pillow,Christopher I. Amos,Lei Lei,M. De Andrade,Xiangjun Gu,Waun Ki Hong,Xifeng Wu +9 more
TL;DR: Dietary intake of ITCs and GSTM1 and GSTT1 genotype information was evaluated in a lung cancer case-control study and found that current smokers who are homozygous null for the GST null genotype and who consume less carcinogenic blocking compounds are at higher lung cancer risk.