M
Marko Noerenberg
Researcher at University of Oxford
Publications - 21
Citations - 810
Marko Noerenberg is an academic researcher from University of Oxford. The author has contributed to research in topics: RNA & RNA-binding protein. The author has an hindex of 10, co-authored 19 publications receiving 463 citations. Previous affiliations of Marko Noerenberg include University of Glasgow & University of Leeds.
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Journal ArticleDOI
The new (dis)order in RNA regulation
TL;DR: This work discusses how disordered protein regions can mediate protein-RNA interactions, conceptually grouping these regions into RS-rich, RG- rich, and other basic sequences, that canMediate both specific and non-specific interactions with RNA.
Journal ArticleDOI
System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection
Manuel Garcia-Moreno,Marko Noerenberg,Shuai Ni,Shuai Ni,Aino I. Järvelin,Esther González-Almela,Caroline E. Lenz,Marcel Bach-Pages,Victoria Cox,Rosario Avolio,Rosario Avolio,T. P. Davis,Svenja Hester,Thibault J. M. Sohier,Bingnan Li,Gregory Heikel,Gracjan Michlewski,Miguel Angel Sanz,Luis Carrasco,Emiliano P. Ricci,Vicent Pelechano,Ilan Davis,Bernd Fischer,Shabaz Mohammed,Alfredo Castello +24 more
TL;DR: RNA availability controls RBP localization and function in SINV-infected cells and is applied to cells challenged with an RNA virus called sindbis (SINV).
Journal ArticleDOI
Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection
Wael Kamel,Marko Noerenberg,Marko Noerenberg,Berati Cerikan,Honglin Chen,Aino I. Järvelin,Mohamed Kammoun,Jeffrey Y. Lee,Ni Shuai,Manuel Garcia-Moreno,Anna Andrejeva,Michael J. Deery,Natasha Johnson,Christopher J. Neufeldt,Mirko Cortese,Michael L. Knight,Kathryn S. Lilley,Javier Martinez,Ilan Davis,Ralf Bartenschlager,Shabaz Mohammed,Shabaz Mohammed,Alfredo Castello,Alfredo Castello +23 more
TL;DR: In this article, the authors employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection.
Journal ArticleDOI
The RNA sensor MDA5 detects SARS-CoV-2 infection.
Natalia G. Sampaio,Lise Chauveau,Jonny Hertzog,Anne Bridgeman,Gerissa Fowler,Jurgen P. Moonen,Maeva Dupont,Rebecca A. Russell,Marko Noerenberg,Jan Rehwinkel +9 more
TL;DR: In this article, the cytosolic RNA sensor MDA5 was identified as a cellular sensor for SARS-CoV-2 infection that induced type I and III interferons and proinflammatory factors such as IL6 and TNF.
Journal ArticleDOI
Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.
Toshana L. Foster,Gary S. Thompson,Arnout P. Kalverda,Jayakanth Kankanala,Matthew Bentham,Laura Wetherill,Joseph Thompson,Amy M. Barker,Dean Clarke,Marko Noerenberg,Arwen R. Pearson,David J. Rowlands,Steven W. Homans,Mark Harris,Richard Foster,Stephen Griffin +15 more
TL;DR: This proof‐of‐principle that structure‐guided design can lead to drug‐like molecules affirms p7 as a much‐needed new target in the burgeoning era of HCV DAA.