Berati Cerikan

TL;DR: Cryo-electron microscopy and tomography is applied to image intact SARS-CoV-2 virions, determining the high-resolution structure, conformational flexibility and distribution of S trimers in situ on the virion surface and providing a basis from which to understand interactions between S and neutralizing antibodies during infection or vaccination.

TL;DR: It is proposed that the genome is packaged around multiple separate vRNP complexes, thereby allowing incorporation of the unusually large coronavirus genome into the virion while maintaining high steric flexibility between the vRNPs.

TL;DR: In insights into virus-induced cytopathic effects, an integrative imaging analysis is employed to determine morphological organelle alterations induced in SARS-CoV-2 infected human lung epithelial cells and 3D electron microscopy reconstructions of whole-cells and subcellular compartments reveal extensive fragmentation of the Golgi apparatus.

TL;DR: Results show that SARS-CoV-2 curates a cGAS-STING mediated NF-κB driven inflammatory immune response in epithelial cells that likely contributes to inflammatory responses seen in patients and might be a target to suppress severe disease symptoms.

TL;DR: In this article, the authors employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection.