A
Arwen R. Pearson
Researcher at University of Hamburg
Publications - 98
Citations - 2581
Arwen R. Pearson is an academic researcher from University of Hamburg. The author has contributed to research in topics: Active site & Terahertz radiation. The author has an hindex of 26, co-authored 91 publications receiving 2025 citations. Previous affiliations of Arwen R. Pearson include University of Minnesota & University of Leeds.
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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Journal ArticleDOI
All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding
TL;DR: The preference of NS5A, in contrast to NS5B, for the polypyrimidine tract highlights an aspect of 3′ UTR RNA recognition by NS5a which may play a role in the control or enhancement of HCV genome replication.
Journal ArticleDOI
MauG, a Novel Diheme Protein Required for Tryptophan Tryptophylquinone Biogenesis†
Yongting Wang,M. Elizabeth Graichen,Aimin Liu,Arwen R. Pearson,Carrie M. Wilmot,Victor L. Davidson +5 more
TL;DR: The biosynthesis of methylamine dehydrogenase from Paracoccus denitrificans requires four genes in addition to those that encode the two structural protein subunits, and one of these, mauG, exhibits sequence similarity to diheme cytochrome c peroxidases and is required for the synthesis of thetryptophan tryptophylquinone (TTQ) prosthetic group of MADH.
Journal ArticleDOI
Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography.
C. Mueller,Alexander Marx,Sascha W. Epp,Yinpeng Zhong,A. Kuo,Aidin R. Balo,Jayashree Soman,Friedrich Schotte,Henrik T. Lemke,Robin L. Owen,Emil F. Pai,Emil F. Pai,Arwen R. Pearson,John S. Olson,Philip A. Anfinrud,Oliver P. Ernst,R. J. Dwayne Miller,R. J. Dwayne Miller,R. J. Dwayne Miller +18 more
TL;DR: The chip concept enables multiple images to be acquired from each crystal, allowing differential detection of changes in diffraction intensities in order to obtain high signal-to-noise and fully exploit the time resolution capabilities of XFELs.
Journal ArticleDOI
Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules.
TL;DR: The information that can be obtained from X-ray crystallography and solution scattering techniques is reviewed and the considerations that must be taken into account when designing a time-resolved experiment are discussed.