M
Markus A. Weigand
Researcher at Heidelberg University
Publications - 324
Citations - 8981
Markus A. Weigand is an academic researcher from Heidelberg University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 41, co-authored 245 publications receiving 7708 citations. Previous affiliations of Markus A. Weigand include German Cancer Research Center & University of Giessen.
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Journal ArticleDOI
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
TL;DR: A critical function of TREM-1 is demonstrated in acute inflammatory responses to bacteria and it is implicate as a potential therapeutic target for septic shock.
Journal ArticleDOI
FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2
Martin R. Sprick,Markus A. Weigand,Markus A. Weigand,Eva Rieser,Charles Rauch,Peter Juo,John Blenis,Peter H. Krammer,Henning Walczak +8 more
TL;DR: Analysis of the native TRAIL death-inducing signaling complex (DISC) revealed ligand-dependent recruitment of FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2.
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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
Birgit Liliensiek,Birgit Liliensiek,Markus A. Weigand,Angelika Bierhaus,Werner Nicklas,Michael Kasper,Stefan Hofer,Jens Plachky,Herman-Josef Gröne,Florian C. Kurschus,Ann Marie Schmidt,Shirley ShiDu Yan,Eike Martin,Erwin Schleicher,David M. Stern,Günter J. Hämmerling,Peter P. Nawroth,Bernd Arnold +17 more
TL;DR: It is shown that deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture and that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.
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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
TL;DR: It is shown that caspase‐10 is recruited not only to the native TRAIL DISC but also to thenative CD95 DISC, and that FADD is necessary for its recruitment to and activation at these two protein complexes.
Journal ArticleDOI
Meta‐analysis of standard, restrictive and supplemental fluid administration in colorectal surgery
Nuh N. Rahbari,Johannes B. Zimmermann,Thomas Schmidt,Moritz Koch,Markus A. Weigand,Jürgen Weitz +5 more
TL;DR: Optimal fluid therapy for colorectal surgery remains uncertain and further research is needed to determine the best treatment strategy.