M
Markus Pfirrmann
Researcher at Ludwig Maximilian University of Munich
Publications - 148
Citations - 7200
Markus Pfirrmann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Imatinib mesylate & Myeloid leukemia. The author has an hindex of 38, co-authored 141 publications receiving 6260 citations. Previous affiliations of Markus Pfirrmann include Heidelberg University.
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Journal ArticleDOI
A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group.
Joerg Hasford,Markus Pfirrmann,Rüdiger Hehlmann,N. C. Allan,Michele Baccarani,J. C. Kluin-Nelemans,Guiliana Alimena,Juan Luis Steegmann,H. Ansari +8 more
TL;DR: A new prognostic scoring system for estimating survival of patients with CML treated with interferon alfa has been developed and validated through use of a large dataset and the ability of the new scoring system to discriminate risk groups was confirmed.
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Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score
Joerg Hasford,Michele Baccarani,Verena S. Hoffmann,Joelle Guilhot,Susanne Saussele,Gianantonio Rosti,François Guilhot,Kimmo Porkka,Gert J. Ossenkoppele,Doris Lindoerfer,Bengt Simonsson,Markus Pfirrmann,Rüdiger Hehlmann +12 more
TL;DR: A new prognostic score that is superior to the Sokal and Euro scores both in its prognostic ability and in its simplicity is described, which can be used to identify CML patients with significantly lower probabilities of responding to therapy and survival, thus alerting physicians to those patients who require closer observation and early intervention.
Journal ArticleDOI
Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial
Susanne Saussele,Johan Richter,Joelle Guilhot,Franz Gruber,Henrik Hjorth-Hansen,Antonio Almeida,Jeroen Janssen,Jiri Mayer,Perttu Koskenvesa,Panayiotis Panayiotidis,Ulla Olsson-Strömberg,Joaquin Martinez-Lopez,Philippe Rousselot,Hanne Vestergaard,Hans Ehrencrona,Veli Kairisto,Katerina Machova Polakova,Martin Müller,Satu Mustjoki,Marc G. Berger,Alice Fabarius,Wolf-Karsten Hofmann,Andreas Hochhaus,Markus Pfirrmann,Francois-Xavier Mahon,Gert J. Ossenkoppele,Maria Pagoni,Stina Söderlund,Martine Escoffre-Barbe,Gabriel Etienne,Jolanta Dengler,Françoise Huguet,Nikolas von Bubnoff,Hana Klamova,Edgar Faber,François Guilhot,Kourosh Lotfi,Delphine Rea,Tim H. Brümmendorf,Gorgine E. de Greef,Leif Stenke,Franck E. Nicolini,Laurence Legros,Andreas Burchert,Jaroslava Voglová,Aude Charbonnier,Emmanuel Gyan,Volker Kunzmann,Peter E. Westerweel +48 more
TL;DR: In this paper, a prospective, non-randomised trial was conducted at 61 European centres in 11 countries to investigate the impact of stopping TKI therapy on the survival of patients with chronic myeloid leukaemia.
Journal ArticleDOI
Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML).
Benjamin Hanfstein,Martin C. Müller,Rüdiger Hehlmann,Philipp Erben,Michael Lauseker,Alice Fabarius,Susanne Schnittger,Claudia Haferlach,Gudrun Göhring,Ulrike Proetel,Hans-Jochem Kolb,Stefan W. Krause,Wolf-K. Hofmann,J. Schubert,H. Einsele,Jolanta Dengler,Mathias Hänel,C. Falge,Lothar Kanz,Andreas Neubauer,Michael Kneba,Frank Stegelmann,Michael Pfreundschuh,Cornelius F. Waller,Susan Branford,Susan Branford,Timothy P. Hughes,Karsten Spiekermann,Gabriela M. Baerlocher,Markus Pfirrmann,Joerg Hasford,Susanne Saußele,Andreas Hochhaus +32 more
TL;DR: Treatment optimization is recommended for pts missing these landmarks and early prediction of prognosis on imatinib is desirable to assure favorable survival or otherwise consider the use of a second-generation tyrosine kinase inhibitor (TKI).
Journal ArticleDOI
Tolerability-Adapted Imatinib 800 mg/d Versus 400 mg/d Versus 400 mg/d Plus Interferon-α in Newly Diagnosed Chronic Myeloid Leukemia
Rüdiger Hehlmann,Michael Lauseker,Susanne Jung-Munkwitz,Armin Leitner,Martin Müller,Nadine Pletsch,Ulrike Proetel,Claudia Haferlach,Brigitte Schlegelberger,Leopold Balleisen,Mathias Hänel,Markus Pfirrmann,Stefan W. Krause,Christoph Nerl,Hans Pralle,Alois Gratwohl,Dieter K. Hossfeld,Joerg Hasford,Andreas Hochhaus,Susanne Saußele +19 more
TL;DR: Early high-dose therapy followed by rapid adaptation to good tolerability increases the rate of major molecular remission (MMR) at 12 months, and achievement of MMR by month 12 is directly associated with improved survival.