M
Markus Ringnér
Researcher at Science for Life Laboratory
Publications - 128
Citations - 18610
Markus Ringnér is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Gene expression profiling & Breast cancer. The author has an hindex of 49, co-authored 119 publications receiving 15744 citations. Previous affiliations of Markus Ringnér include VTT Technical Research Centre of Finland & Lund University.
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Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma
Mattias Aine,Gottfrid Sjödahl,Pontus Eriksson,Srinivas Veerla,David Lindgren,Markus Ringnér,Mattias Höglund +6 more
TL;DR: Genome-wide DMR methylation patterns are reflected in the gene expression subtypes of UC, and an epigenetic switch involving the HOXA-genes with associations to tumor differentiation states and patient prognosis is characterized.
Journal ArticleDOI
Genomic and transcriptional alterations in lung adenocarcinoma in relation to smoking history.
Anna Karlsson,Markus Ringnér,Martin Lauss,Johan Botling,Patrick Micke,Maria Planck,Johan Staaf +6 more
TL;DR: The results support a molecularly distinct less aggressive adenocarcinoma entity, arising in never-smokers and a subset of smokers, and emphasize the clinical importance of accurate molecular characterization of lung adenOCarcinomas.
The CD44 + /CD24 - phenotype is enriched in basal-like breast
Pär-Ola Bendahl,Markus Ringnér,Lao H. Saal,Sofia Gruvberger,Kristina Lövgren,Dorthe Grabau,Mårten Fernö,Åke Borg,Cecilia Hegardt,Gabriella Honeth +9 more
TL;DR: An association between basal-like and particularly BRCA1 hereditary breast cancer and the presence of CD44+/CD24- cells is demonstrated, demonstrating that a putative tumorigenic ability may not be confined to cells of this phenotype and that other breast cancer stem cell markers remain to be identified.
Journal ArticleDOI
Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
Yingchun Liu,Markus Ringnér +1 more
TL;DR: This work presents a strategy for identifying cell signaling pathways whose deregulation results in an observed expression signature and evaluates the strategy using six human and mouse gene expression signatures.
Journal ArticleDOI
Prognostic and Chemotherapy Predictive Value of Gene-Expression Phenotypes in Primary Lung Adenocarcinoma
TL;DR: In a large-scale evaluation, GEPs add prognostic value to standard clinicopathologic variables in lung adenocarcinoma, and are associated with patient outcome in both univariate and multivariate analyses, although not in all individual cohorts.