M
Markus Ringnér
Researcher at Science for Life Laboratory
Publications - 128
Citations - 18610
Markus Ringnér is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Gene expression profiling & Breast cancer. The author has an hindex of 49, co-authored 119 publications receiving 15744 citations. Previous affiliations of Markus Ringnér include VTT Technical Research Centre of Finland & Lund University.
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Journal Article
The gene expression response of breast cancer to growth regulators: Patterns and correlation with tumor expression profiles
Heather E. Cunliffe,Markus Ringnér,Sven Bilke,Robert L. Walker,Jennifer M. Cheung,Yi Chen,Paul S. Meltzer +6 more
TL;DR: The overall impact at the gene expression level of diverse regulators of breast cancer growth is highlighted and the behavior of breast cancers cells in culture is linked to important clinical properties of human breast tumors.
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Molecular Profiling Reveals Low- and High-Grade Forms of Primary Melanoma
Katja Harbst,Johan Staaf,Martin Lauss,Anna Karlsson,Anna Måsbäck,Iva Johansson,Pär-Ola Bendahl,Johan Vallon-Christersson,Therese Törngren,Henrik Ekedahl,Jürgen Geisler,Mattias Höglund,Markus Ringnér,Lotta Lundgren,Karin Jirström,Håkan Olsson,Christian Ingvar,Åke Borg,Hensin Tsao,Göran Jönsson +19 more
TL;DR: Evidence is provided for a molecular organization within melanomas, which is preserved across all stages of disease, and a binary subtype-based signature capable of distinguishing between “high” and “low” grade forms of the disease is developed.
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Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Marcel Smid,Germán Fg Rodríguez-González,Anieta M. Sieuwerts,Roberto Salgado,Roberto Salgado,Wendy Wj Prager-Van der Smissen,Michelle van der Vlugt-Daane,Anne A van Galen,Serena Nik-Zainal,Serena Nik-Zainal,Johan Staaf,Arie B. Brinkman,Marc J. van de Vijver,Andrea L. Richardson,Aquila Fatima,Kim Berentsen,Adam A Butler,Sancha Martin,Helen Davies,Reno Debets,Marion E Meijer-Van Me Gelder,Carolien Ch van Deurzen,Gaëtan MacGrogan,Gert Van den Eynden,Gert Van den Eynden,Colin A. Purdie,Alastair M Thompson,Carlos Caldas,Paul N. Span,Peter T. Simpson,Sunil R. Lakhani,Sunil R. Lakhani,Steven Van Laere,Christine Desmedt,Markus Ringnér,Stefania Tommasi,Jorunn J Eyford,Annegien Broeks,Anne Vincent-Salomon,P. Andrew Futreal,Stian Knappskog,Tari Ta King,Gilles Thomas,Alain Viari,Anita Langerød,Anne Lise Børresen-Dale,Ewan Birney,Hendrik G. Stunnenberg,Mike M Stratton,John A. Foekens,John W.M. Martens +50 more
TL;DR: It is validated that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1 and that substitutions of a particular type are more effective in doing so than others.
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Genome-wide DNA Methylation Analysis of Lung Carcinoma Reveals One Neuroendocrine and Four Adenocarcinoma Epitypes Associated with Patient Outcome
Anna Karlsson,Mats Jönsson,Martin Lauss,Hans Brunnström,Per Jönsson,Åke Borg,Göran Jönsson,Markus Ringnér,Maria Planck,Johan Staaf +9 more
TL;DR: This study demonstrates the possibility to further subgroup lung cancer, and more specifically adenocarcinomas, based on epigenetic/molecular classification that could lead to more accurate tumor classification, prognostication, and tailored patient therapy.
Journal ArticleDOI
Endothelial induced EMT in breast epithelial cells with stem cell properties.
Valgardur Sigurdsson,Bylgja Hilmarsdottir,Hekla Sigmundsdottir,Agla J. Fridriksdottir,Markus Ringnér,René Villadsen,Åke Borg,Bjarni A. Agnarsson,Ole W. Petersen,Magnus K. Magnusson,Thorarinn Gudjonsson +10 more
TL;DR: It is shown in a 3D culture model that endothelial cells are potent inducers of EMT in breast epithelial cells with stem cell properties and basal-like breast cancer contains cells with an EMT phenotype, most prominently close to vascular rich areas of these tumors.