M
Markus Ringnér
Researcher at Science for Life Laboratory
Publications - 128
Citations - 18610
Markus Ringnér is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Gene expression profiling & Breast cancer. The author has an hindex of 49, co-authored 119 publications receiving 15744 citations. Previous affiliations of Markus Ringnér include VTT Technical Research Centre of Finland & Lund University.
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Journal ArticleDOI
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Johan Staaf,Johan Vallon-Christersson,David Lindgren,Gunnar Juliusson,Richard Rosenquist,Mattias Höglund,Åke Borg,Markus Ringnér +7 more
TL;DR: The proposed normalization strategy represents a valuable tool that improves the quality of data obtained from Illumina Infinium arrays, in particular when used for LOH and copy number variation studies.
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High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer
Johan Staaf,Göran Jönsson,Markus Ringnér,Johan Vallon-Christersson,Dorthe Grabau,Adalgeir Arason,Haukur Gunnarsson,Bjarni A. Agnarsson,P Malmström,Oskar T. Johannsson,Niklas Loman,Rosa B. Barkardottir,Åke Borg +12 more
TL;DR: A comprehensive survey of CNAs in HER2+ breast tumors is performed, pinpointing significant genomic alterations including both known and potentially novel therapeutic targets, which sheds further light on the genomically complex and heterogeneous nature of HER2- tumors in relation to other subgroups of breast cancer.
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Folding free energies of 5'-UTRs impact post-transcriptional regulation on a genomic scale in yeast.
Markus Ringnér,Morten Krogh +1 more
TL;DR: It is concluded that there is a widespread bias for 5′-UTRs to be weakly folded, folding free energies of 5′–untranslated regions (UTRs) are correlated with mRNA translation and turnover on a genomic scale, and transcripts with strongly foldable genes are often rare and hard to find experimentally.
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Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Göran Jönsson,Christina Dahl,Johan Staaf,T Sandberg,Pär-Ola Bendahl,Markus Ringnér,Per Guldberg,Åke Borg +7 more
TL;DR: For the first time, alterations of the various melanoma genes were associated with distinct chromosomal imbalances suggestive of specific genomic programs in melanoma development.
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Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker
Ida Johansson,Cecilia Nilsson,Pontus Berglund,Martin Lauss,Markus Ringnér,Håkan Olsson,Lena Luts,Edith Sim,Sten Thorstensson,Marie-Louise Fjällskog,Ingrid Hedenfalk +10 more
TL;DR: The aim of the present study was to characterize MBC tumors transcriptionally, to classify them into comprehensive subgroups, and to compare them with female breast cancer (FBC), and to identify NAT1 as a possible prognostic biomarker for MBC.