M
Markus Sack
Researcher at RWTH Aachen University
Publications - 75
Citations - 5070
Markus Sack is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Antibody & Fusion protein. The author has an hindex of 34, co-authored 73 publications receiving 4473 citations. Previous affiliations of Markus Sack include Fraunhofer Society.
Papers
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Journal ArticleDOI
COVID-19 vaccine development and a potential nanomaterial path forward.
Matthew D Shin,Sourabh Shukla,Young Hun Chung,Veronique Beiss,Soo Khim Chan,Oscar A Ortega-Rivera,David M. Wirth,Angela Chen,Markus Sack,Jonathan K. Pokorski,Nicole F. Steinmetz +10 more
TL;DR: Current approaches to COVID-19 vaccine development are highlighted, highlighting the role of nanotechnology, manufacturing and distribution and a successful vaccine platform must enable rapid discovery, scalable manufacturing and global distribution.
Journal ArticleDOI
Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium
Philipp von Hundelshausen,Rory R. Koenen,Markus Sack,Sebastian F. Mause,Wencke Adriaens,Amanda E. I. Proudfoot,Tilman M. Hackeng,Christian Weber +7 more
TL;DR: The results suggest that heterophilic interactions with PF4 require structural motifs important in RANTES oligomerization and amplify RantES-triggered effects on monocyte adhesion, which may have implications for the modulation of inflammatory recruitment by platelet-derived chemokines.
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Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies.
Eva Stoger,Carmen Vaquero,Esperanza Torres,Markus Sack,Liz Nicholson,Jürgen Drossard,Sarah Williams,Duncan Keen,Yolande Perrin,Paul Christou,Rainer Fischer +10 more
TL;DR: The stable expression of a medically important antibody in the staple cereal crops rice and wheat is described, establishing that molecular pharming in cereals can be a viable production system for such high-value pharmaceutical macromolecules.
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Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves.
Carmen Vaquero,Markus Sack,John S. Chandler,Jürgen Drossard,Flora Schuster,Michael Monecke,Stefan Schillberg,Rainer Fischer +7 more
TL;DR: In this paper, a recombinant single-chain Fv antibody (scFvT84.66) and a full-size mouse/human chimeric antibody derived from the parental murine mAb T 84.66 specific for the human carcinoembryonic antigen were engineered into a plant expression vector.
Journal ArticleDOI
Plantibodies: applications, advantages and bottlenecks.
TL;DR: Recent research developments focus on the fine-tuning of expression systems and the detailed characterisation of recombinant products, including the implications of plant-specific glycosylation.