Markus Stoeckli

TL;DR: Imaging MS joins techniques such as immunochemistry and fluorescence microscopy for the study of the spatial arrangement of molecules within biological tissues for the unraveling and understanding the molecular complexities of cells.

TL;DR: The synthesis and characterization of the near-infrared fluorescence oxazine dye AOI987 is described, which readily penetrate the intact blood-brain barrier and binds to amyloid plaques and is an attractive probe to noninvasively monitor disease progression in animal models of Alzheimer disease and to evaluate effects of potential Alzheimer disease drugs on the plaque load.

TL;DR: The technique described in this article, termed matrix-assisted laser desorption/ionization (MALDI) mass spectrometric imaging, can fill the gap by simultaneously measuring compound and multiple metabolites distributed in whole-body tissue sections, using non-labeled compounds.

TL;DR: The direct profiling of proteins present in tissue sections for several organs of the mouse has been accomplished using matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), with unique protein profiles measured from these tissue blots.

TL;DR: An overview of the possibilities of Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) will be given, which can be used to track biomarkers such as peptides or proteins but also to map drug/tissue interactions.