M
Markus W. Ribbe
Researcher at University of California, Irvine
Publications - 138
Citations - 6240
Markus W. Ribbe is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Nitrogenase & FeMoco. The author has an hindex of 42, co-authored 128 publications receiving 5382 citations. Previous affiliations of Markus W. Ribbe include University of California.
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Journal ArticleDOI
X-ray Emission Spectroscopy Evidences a Central Carbon in the Nitrogenase Iron-Molybdenum Cofactor
Kyle M. Lancaster,Michael Roemelt,Patrick Ettenhuber,Yilin Hu,Markus W. Ribbe,Frank Neese,Frank Neese,Uwe Bergmann,Serena DeBeer,Serena DeBeer +9 more
TL;DR: A central light atom in a cofactor at the nitrogenase active site is identified as a carbon, indicating that among the candidate atoms oxygen, nitrogen, and carbon, it is carbon that best fits the XES data.
Journal ArticleDOI
Molybdenum cofactors, enzymes and pathways
TL;DR: The biosynthetic pathways leading to both types of cofactor have common mechanistic aspects relating to scaffold formation, metal activation and cofactor insertion into apoenzymes, and have served as an evolutionary 'toolbox' to mediate additional cellular functions in eukaryotic metabolism.
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Vanadium Nitrogenase Reduces CO
TL;DR: An enzyme that reduces nitrogen to ammonia can also reduce carbon monoxide to hydrocarbons and the parallelism between the two reactions suggests a potential link in mechanism and evolution between the carbon and nitrogen cycles on Earth.
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Radical SAM-dependent Carbon Insertion Into the Nitrogenase M-cluster
TL;DR: Radiolabeling experiments show that this carbide originates from the methyl group of S-adenosylmethionine (SAM) and that it is inserted into the M-cluster by the assembly protein NifB, an initial step toward unraveling the importance of the interstitial carbide and providing insights into the nitrogenase mechanism.
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Extending the Carbon Chain: Hydrocarbon Formation Catalyzed by Vanadium/Molybdenum Nitrogenases
TL;DR: The identification of CO as a substrate for both molybdenum- and vanadium-nitrogenases strengthens the hypothesis that CO reduction is an evolutionary relic of the function of the nitrogenase family.