M
Marla J. Keller
Researcher at Albert Einstein College of Medicine
Publications - 60
Citations - 2163
Marla J. Keller is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Microbicide & Herpes simplex virus. The author has an hindex of 25, co-authored 58 publications receiving 1674 citations. Previous affiliations of Marla J. Keller include Yeshiva University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.
Carl A. Pierce,Paula Preston-Hurlburt,Yile Dai,Clare Burn Aschner,Natalia Cheshenko,Benjamin T. Galen,Scott J. Garforth,Natalia G. Herrera,Rohit K. Jangra,Nicholas C. Morano,Erika P. Orner,Sharlene Sy,Kartik Chandran,James Dziura,Steven C. Almo,Aaron M. Ring,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +18 more
TL;DR: The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
Journal ArticleDOI
Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety
Pedro M. M. Mesquita,Natalia Cheshenko,Sarah S. Wilson,Mohak Mhatre,Esmeralda Guzman,Esra Fakioglu,Marla J. Keller,Betsy C. Herold +7 more
TL;DR: Epithelial barrier disruption and enhanced viral replication may have contributed to the increased risk of HIV acquisition observed in phase 3 trials of N-9 and CS.
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Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19.
Marla J. Keller,Elizabeth A. Kitsis,Shitij Arora,Jen Ting Chen,Shivani Agarwal,Michael W. Ross,Yaron Tomer,William N. Southern +7 more
TL;DR: Whether glucocorticoid treatment is associated with changes in mortality or mechanical ventilation in patients with high or low CRP needs study in prospective, randomized clinical trials.
Journal ArticleDOI
Natural mucosal barriers and COVID-19 in children.
Carl A. Pierce,Sharlene Sy,Benjamin T. Galen,Y. Goldstein,Erika P. Orner,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +7 more
TL;DR: In this article, the authors hypothesize that a robust early innate immune response to SARS coronavirus 2 (SARS-CoV-2) protects against severe disease.
Journal ArticleDOI
TLR7 induces anergy in human CD4+ T cells
Margarita Dominguez-Villar,Anne-Sophie Gautron,Marine de Marcken,Marla J. Keller,David A. Hafler +4 more
TL;DR: Engagement of TLR7 in CD4+ T cells induced intracellular calcium flux with activation of an anergic gene-expression program dependent on the transcription factor NFATc2, as well as unresponsiveness of T cells, which elucidate a previously unknown function for microbial pattern–recognition receptors in the downregulation of immune responses.