A
Aaron M. Ring
Researcher at Yale University
Publications - 127
Citations - 12946
Aaron M. Ring is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & Antibody. The author has an hindex of 44, co-authored 113 publications receiving 8125 citations. Previous affiliations of Aaron M. Ring include Howard Hughes Medical Institute & Stanford University.
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Journal ArticleDOI
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
Sydney Gordon,Roy Louis Maute,Ben W. Dulken,Gregor Hutter,Gregor Hutter,Benson M. George,Melissa N. McCracken,Rohit Gupta,Jonathan M. Tsai,Rahul Sinha,Daniel M. Corey,Aaron M. Ring,Andrew J. Connolly,Irving L. Weissman +13 more
TL;DR: It is shown that both mouse and human TAMs express programmed cell death protein 1, and blockade of PD-1–PD-L1 in vivo increases macrophage phagocytosis, reduces tumour growth and lengthens the survival of mice in mouse models of cancer in a macrophages-dependent fashion.
Journal ArticleDOI
Sex differences in immune responses that underlie COVID-19 disease outcomes.
Takehiro Takahashi,Mallory K. Ellingson,Patrick Wong,Benjamin Israelow,Carolina Lucas,Jon Klein,Julio Silva,Tianyang Mao,Ji Eun Oh,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Feimei Liu,Amit Meir,Jonathan Sun,Eric Wang,Arnau Casanovas-Massana,Anne L. Wyllie,Chantal B.F. Vogels,Rebecca Earnest,Sarah Lapidus,Isabel M. Ott,Adam J. Moore,Albert C. Shaw,John Fournier,Camila D. Odio,Shelli F. Farhadian,Charles S. Dela Cruz,Nathan D. Grubaugh,Wade L. Schulz,Aaron M. Ring,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +35 more
TL;DR: Examination of sex differences in viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines and blood-cell phenotyping in patients with moderate COVID-19 found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.
Journal ArticleDOI
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse,Aaron M. Ring,Aashish Manglik,Jianxin Hu,Kelly Hu,Katrin Eitel,Harald Hübner,Els Pardon,Celine Valant,Patrick M. Sexton,Arthur Christopoulos,Christian C. Felder,Peter Gmeiner,Jan Steyaert,William I. Weis,K. Christopher Garcia,Jürgen Wess,Brian K. Kobilka +17 more
TL;DR: The structure of an agonist-bound, active state of the human M2 muscarinic acetylcholine receptor stabilized by a G-protein mimetic camelid antibody fragment isolated by conformational selection using yeast surface display reveals larger conformational changes in the extracellular region and orthosteric binding site than observed in the active states of the β2AR and rhodopsin.
Journal ArticleDOI
Neuroinvasion of SARS-CoV-2 in human and mouse brain.
Eric Song,Ce Zhang,Benjamin Israelow,Alice Lu-Culligan,Alba Vieites Prado,Sophie Skriabine,Peiwen Lu,Orr-El Weizman,Feimei Liu,Yile Dai,Klara Szigeti-Buck,Yuki Yasumoto,Guilin Wang,Christopher Castaldi,Jaime Heltke,Evelyn Ng,John Wheeler,Mia Madel Alfajaro,Etienne Levavasseur,Benjamin Fontes,Neal G. Ravindra,David van Dijk,Shrikant Mane,Murat Gunel,Aaron M. Ring,Syed A. Jaffar Kazmi,Kai Zhang,Craig B. Wilen,Tamas L. Horvath,Isabelle Plu,Stéphane Haïk,Jean-Leon Thomas,Jean-Leon Thomas,Angeliki Louvi,Shelli F. Farhadian,Anita Huttner,Danielle Seilhean,Nicolas Renier,Kaya Bilguvar,Akiko Iwasaki,Akiko Iwasaki +40 more
Abstract: Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons. However, no evidence for type I interferon responses was detected. We demonstrate that neuronal infection can be prevented by blocking ACE2 with antibodies or by administering cerebrospinal fluid from a COVID-19 patient. Second, using mice overexpressing human ACE2, we demonstrate SARS-CoV-2 neuroinvasion in vivo. Finally, in autopsies from patients who died of COVID-19, we detect SARS-CoV-2 in cortical neurons and note pathological features associated with infection with minimal immune cell infiltrates. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and an unexpected consequence of direct infection of neurons by SARS-CoV-2.
Journal ArticleDOI
Diverse Functional Autoantibodies in Patients with COVID-19.
Eric Wang,Tianyang Mao,Jon Klein,Yile Dai,John D. Huck,Jillian R. Jaycox,Feimei Liu,Ting Zhou,Benjamin Israelow,Patrick Wong,Andreas Coppi,Carolina Lucas,Julio Silva,Ji Eun Oh,Eric Song,Emily S. Perotti,Neil S Zheng,Suzanne Fischer,Melissa Campbell,John Fournier,Anne L. Wyllie,Chantal B.F. Vogels,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Anne E. Watkins,Charles S. Dela Cruz,Shelli F. Farhadian,Wade L. Schulz,Shuangge Ma,Nathan D. Grubaugh,Albert I. Ko,Akiko Iwasaki,Akiko Iwasaki,Aaron M. Ring +34 more
TL;DR: In this article, a high-throughput autoantibody discovery technique known as rapid extracellular antigen profiling was used to screen a cohort of 194 individuals infected with SARS-CoV-2, comprising 172 patients with COVID-19 and 22 health care workers with mild disease or asymptomatic infection, for auto-antibodies against 2,770 proteins (members of the exoproteome).