S
Scott J. Garforth
Researcher at Albert Einstein College of Medicine
Publications - 49
Citations - 1827
Scott J. Garforth is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: DNA & Immune system. The author has an hindex of 19, co-authored 44 publications receiving 1308 citations. Previous affiliations of Scott J. Garforth include University of Sheffield & Royal Hallamshire Hospital.
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Journal ArticleDOI
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.
Carl A. Pierce,Paula Preston-Hurlburt,Yile Dai,Clare Burn Aschner,Natalia Cheshenko,Benjamin T. Galen,Scott J. Garforth,Natalia G. Herrera,Rohit K. Jangra,Nicholas C. Morano,Erika P. Orner,Sharlene Sy,Kartik Chandran,James Dziura,Steven C. Almo,Aaron M. Ring,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +18 more
TL;DR: The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
Journal ArticleDOI
A naturally occurring antiviral ribonucleotide encoded by the human genome
Anthony S. Gizzi,Tyler L. Grove,Jamie J. Arnold,Joyce Jose,Rohit K. Jangra,Scott J. Garforth,Quan Du,Sean M. Cahill,Natalya G. Dulyaninova,J. Love,Kartik Chandran,Anne R. Bresnick,Craig E. Cameron,Steven C. Almo +13 more
TL;DR: These findings suggest a partially unifying mechanism for the broad antiviral effects of viperin that is based on the intrinsic enzymatic properties of the protein and involves the generation of a naturally occurring replication-chain terminator encoded by mammalian genomes.
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Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation
Wen-I Tsou,Khanh Quynh N. Nguyen,Daniel A. Calarese,Scott J. Garforth,Anita Antes,Sergey V. Smirnov,Steve C. Almo,Raymond B. Birge,Sergei V. Kotenko +8 more
TL;DR: It is demonstrated that, despite their similarity, TYRO3, AXL, and MER are likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs.
Journal ArticleDOI
Panoramic view of a superfamily of phosphatases through substrate profiling
Hua Huang,Chetanya Pandya,Chunliang Liu,Nawar Al-Obaidi,Min Wang,Li Zheng,Sarah Toews Keating,Miyuki Aono,J. Love,Brandon Evans,R.D. Seidel,B. Hillerich,Scott J. Garforth,Steven C. Almo,Patrick S. Mariano,Debra Dunaway-Mariano,Karen N. Allen,Jeremiah D. Farelli +17 more
TL;DR: The functional space of the ubiquitous haloalkanoate dehalogenase superfamily (HADSF) was revealed by screening a customized substrate library against >200 enzymes from representative prokaryotic species, enabling inferred annotation of ∼35% of the HADSF.
Journal ArticleDOI
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Jessica R. Ingram,Olga S. Blomberg,Mohammad Rashidian,Lestat R. Ali,Scott J. Garforth,Elena V. Fedorov,Alexander A. Fedorov,Jeffrey B. Bonanno,Camille Le Gall,Stephanie J. Crowley,Camilo Espinosa,Tamara Biary,Edmund J. Keliher,Ralph Weissleder,Steven C. Almo,Stephanie K. Dougan,Hidde L. Ploegh,Michael Dougan +17 more
TL;DR: It is demonstrated that CTLA-4–binding antibodies require an Fc domain for antitumor effect, and H11, a high-affinity alpaca heavy chain-only antibody fragment against CTLA -4, has minimal effects on antitUMor responses.