R
Rohit K. Jangra
Researcher at Albert Einstein College of Medicine
Publications - 74
Citations - 4184
Rohit K. Jangra is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Viral entry & Virus. The author has an hindex of 26, co-authored 67 publications receiving 3095 citations. Previous affiliations of Rohit K. Jangra include University of Texas Medical Branch & Indian Veterinary Research Institute.
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Journal ArticleDOI
Broad neutralization of SARS-related viruses by human monoclonal antibodies.
Anna Z. Wec,Daniel Wrapp,Andrew S. Herbert,Daniel P. Maurer,Denise Haslwanter,Mrunal Sakharkar,Rohit K. Jangra,M. Eugenia Dieterle,Asparouh Lilov,Deli Huang,Longping V. Tse,Nicole V. Johnson,Ching-Lin Hsieh,Nianshuang Wang,Juergen Hermann Nett,Elizabeth Champney,Irina Burnina,Michael G. Brown,Shu Lin,Melanie Sinclair,Carl Hirschie Johnson,Sarat Pudi,Robert H. Bortz,Ariel S. Wirchnianski,Ethan Laudermilch,Catalina Florez,J. Maximilian Fels,Cecilia M. O’Brien,Barney S. Graham,David Nemazee,Dennis R. Burton,Ralph S. Baric,James E. Voss,Kartik Chandran,John M. Dye,Jason S. McLellan,Laura M. Walker +36 more
TL;DR: Hundreds of antibodies against the viral spike protein of SARS-CoV-2 are isolated from the memory B cells of a survivor of the 2003 outbreak and reveal a target for the rational design of pan-sarbecovirus vaccines.
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Stabilization of hepatitis C virus RNA by an Ago2–miR-122 complex
Tetsuro Shimakami,Daisuke Yamane,Rohit K. Jangra,Rohit K. Jangra,Brian J. Kempf,Carolyn Spaniel,David J. Barton,Stanley M. Lemon +7 more
TL;DR: It is demonstrated that a RISC-like complex mediates the stability of HCV RNA and suggested that Ago2 and miR-122 act coordinately to protect the viral genome from 5′ exonuclease activity of the host mRNA decay machinery.
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Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122
TL;DR: It is concluded that miR-122 promotes replication by binding directly to both sites in the genomic RNA and, at least in part, by stimulating internal ribosome entry site (IRES)-mediated translation.
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Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.
Carl A. Pierce,Paula Preston-Hurlburt,Yile Dai,Clare Burn Aschner,Natalia Cheshenko,Benjamin T. Galen,Scott J. Garforth,Natalia G. Herrera,Rohit K. Jangra,Nicholas C. Morano,Erika P. Orner,Sharlene Sy,Kartik Chandran,James Dziura,Steven C. Almo,Aaron M. Ring,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +18 more
TL;DR: The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses
Tracey Goldstein,Simon J. Anthony,Simon J. Anthony,Aiah Gbakima,Brian H. Bird,James Bangura,Alexandre Tremeau-Bravard,Manjunatha N. Belaganahalli,Heather L. Wells,Jasjeet K. Dhanota,Eliza Liang,Eliza Liang,Michael G. Grodus,Rohit K. Jangra,Veronica A. DeJesus,Gorka Lasso,Brett R. Smith,Amara Jambai,Brima O. Kamara,Sorie Kamara,William Bangura,Corina Monagin,Sagi Shapira,Christine K. Johnson,Karen Saylors,Edward M. Rubin,Kartik Chandran,W. Ian Lipkin,Jonna A. K. Mazet +28 more
TL;DR: It is shown that the viral glycoprotein can mediate entry into human cells, and whether exposure has actually occurred or if BOMV is pathogenic in humans is investigated.