M
Marta Martinez-Vincente
Researcher at Albert Einstein College of Medicine
Publications - 1
Citations - 365
Marta Martinez-Vincente is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Proteasome & Lysosome. The author has an hindex of 1, co-authored 1 publications receiving 334 citations.
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie M. Thompson,Charity T. Aiken,Linda S. Kaltenbach,Namita Agrawal,Katalin Illes,Ali Khoshnan,Marta Martinez-Vincente,Montserrat Arrasate,Jacqueline G. O’Rourke,Hasan Khashwji,Tamas Lukacsovich,Ya-Zhen Zhu,Alice L. Lau,Ashish C. Massey,Michael R. Hayden,Scott Zeitlin,Steven Finkbeiner,Kim N. Green,Frank M. LaFerla,Gillian P. Bates,Lan Huang,Paul H. Patterson,Donald C. Lo,Ana Maria Cuervo,J. Lawrence Marsh,Joan S. Steffan +25 more
TL;DR: The protein mutated in Huntington's disease is phosphorylated by the inflammatory kinase IKK, which promotes other post-translational modifications, and protein degradation.