Y
Ya-Zhen Zhu
Researcher at University of California, Irvine
Publications - 15
Citations - 6657
Ya-Zhen Zhu is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Huntingtin & Huntingtin Protein. The author has an hindex of 14, co-authored 14 publications receiving 6394 citations.
Papers
More filters
Journal ArticleDOI
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Joan S. Steffan,László Bodai,Judit Pallos,Marnix Poelman,Alexander McCampbell,Barbara L. Apostol,Alexsey Kazantsev,Emily Schmidt,Ya-Zhen Zhu,Marilee Greenwald,Riki Kurokawa,David E. Housman,George R. Jackson,J. Lawrence Marsh,Leslie M. Thompson +14 more
TL;DR: It is shown that the polyglutamine-containing domain of Htt, Htt exon 1 protein (Httex1p), directly binds the acetyltransferase domains of two distinct proteins: CREB-binding protein (CBP) and p300/CBP-associated factor (P/CAF).
Journal ArticleDOI
Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.
Rita Shiang,Leslie M. Thompson,Ya-Zhen Zhu,Deanna M. Church,Thomas J. Fielder,Maureen Bocian,Sara T. Winokur,John J. Wasmuth +7 more
TL;DR: DNA studies revealed point mutations in the FGFR3 gene in ACH heterozygotes and homozygotes, which result in the substitution of an arginine residue for a glycine at position 380 of the mature protein, which is in the transmembrane domain ofFGFR3.
Journal ArticleDOI
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
Joan S. Steffan,Aleksey G. Kazantsev,Olivera Spasic-Boskovic,Marilee Greenwald,Ya-Zhen Zhu,Heike Göhler,Erich E. Wanker,Gillian P. Bates,David E. Housman,Leslie M. Thompson +9 more
TL;DR: The possibility that expanded repeat htt causes aberrant transcriptional regulation through its interaction with cellular transcription factors which may result in neuronal dysfunction and cell death in HD is raised.
Journal ArticleDOI
SUMO modification of Huntingtin and Huntington's disease pathology
Joan S. Steffan,Namita Agrawal,Judit Pallos,Erica Rockabrand,Lloyd C. Trotman,Natalia Slepko,Katalin Illes,Tamas Lukacsovich,Ya-Zhen Zhu,Elena Cattaneo,Pier Paolo Pandolfi,Leslie M. Thompson,J. Lawrence Marsh +12 more
TL;DR: It is reported that a pathogenic fragment of Htt (Httex1p) can be modified either by small ubiquitin-like modifier (SUMO)–1 or by ubiquit in on identical lysine residues.
Journal ArticleDOI
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
Patricia L. Tavormina,Rita Shiang,Leslie M. Thompson,Ya-Zhen Zhu,Douglas J. Wilkin,Ralph S. Lachman,William R. Wilcox,David L. Rimoin,Daniel H. Cohn,John J. Wasmuth +9 more
TL;DR: None of these mutations were found in 50 controls showing that mutations affecting different functional domains of FGFR3 cause different forms of this lethal disorder.