C
Charity T. Aiken
Researcher at University of California, Irvine
Publications - 4
Citations - 936
Charity T. Aiken is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Huntingtin & Proteasome. The author has an hindex of 4, co-authored 4 publications receiving 851 citations.
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Journal ArticleDOI
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie M. Thompson,Charity T. Aiken,Linda S. Kaltenbach,Namita Agrawal,Katalin Illes,Ali Khoshnan,Marta Martinez-Vincente,Montserrat Arrasate,Jacqueline G. O’Rourke,Hasan Khashwji,Tamas Lukacsovich,Ya-Zhen Zhu,Alice L. Lau,Ashish C. Massey,Michael R. Hayden,Scott Zeitlin,Steven Finkbeiner,Kim N. Green,Frank M. LaFerla,Gillian P. Bates,Lan Huang,Paul H. Patterson,Donald C. Lo,Ana Maria Cuervo,J. Lawrence Marsh,Joan S. Steffan +25 more
TL;DR: The protein mutated in Huntington's disease is phosphorylated by the inflammatory kinase IKK, which promotes other post-translational modifications, and protein degradation.
Journal ArticleDOI
Oxidative Stress-Mediated Regulation of Proteasome Complexes
TL;DR: Better understanding of molecular mechanisms underlying proteasome function in response to oxidative stress will provide a basis for developing new strategies aimed at improving cell viability and recovery as well as attenuating oxidation-induced cytotoxicity associated with aging and disease.
Journal ArticleDOI
Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Charity T. Aiken,Joan S. Steffan,Cortnie Guerrero,Hasan Khashwji,Tamas Lukacsovich,Danielle A. Simmons,Judy Purcell,Kimia Menhaji,Ya-Zhen Zhu,Kim N. Green,Frank M. LaFerla,Lan Huang,Leslie M. Thompson,J. Lawrence Marsh +13 more
TL;DR: It is demonstrated that pThr-3 occurs on full-length Htt in vivo, and that this modification affects the aggregation and pathogenic properties of Htt, and therapeutic strategies that modulate these events could in turn affect Htt pathogenesis.
Journal ArticleDOI
A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis
Giulia Ossato,Michelle A. Digman,Charity T. Aiken,Tamas Lukacsovich,J. Lawrence Marsh,Enrico Gratton +5 more
TL;DR: The use of the recently developed number and brightness method (N&B) that uses confocal images to monitor aggregation of Huntingtin exon 1 protein (Httex1p) directly in living cells shows a two-step pathway leading to inclusion formation that is polyQ length dependent and involves four phases.