L
Lan Huang
Researcher at University of California, Irvine
Publications - 191
Citations - 11645
Lan Huang is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Proteasome & Phosphorylation. The author has an hindex of 57, co-authored 167 publications receiving 10242 citations. Previous affiliations of Lan Huang include University of California, San Francisco & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection
Silvio M. Zanata,Marilene H. Lopes,Adriana F. Mercadante,Glaucia N. M. Hajj,Luciana B. Chiarini,Regina Nomizo,Adriana Freitas,A. L. B. Cabral,Kil Sun Lee,Maria A. Juliano,Elizabeth de Oliveira,Saul G. Jachieri,Alma L. Burlingame,Lan Huang,Rafael Linden,Ricardo R. Brentani,Vilma R. Martins +16 more
TL;DR: Cell surface binding and pull‐down experiments showed that recombinant PrPc binds to cellular STI1, and co‐immunoprecipitation assays strongly suggest that both proteins are associated in vivo.
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie M. Thompson,Charity T. Aiken,Linda S. Kaltenbach,Namita Agrawal,Katalin Illes,Ali Khoshnan,Marta Martinez-Vincente,Montserrat Arrasate,Jacqueline G. O’Rourke,Hasan Khashwji,Tamas Lukacsovich,Ya-Zhen Zhu,Alice L. Lau,Ashish C. Massey,Michael R. Hayden,Scott Zeitlin,Steven Finkbeiner,Kim N. Green,Frank M. LaFerla,Gillian P. Bates,Lan Huang,Paul H. Patterson,Donald C. Lo,Ana Maria Cuervo,J. Lawrence Marsh,Joan S. Steffan +25 more
TL;DR: The protein mutated in Huntington's disease is phosphorylated by the inflammatory kinase IKK, which promotes other post-translational modifications, and protein degradation.
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A Tandem Affinity Tag for Two-step Purification under Fully Denaturing Conditions Application in Ubiquitin Profiling and Protein Complex Identification Combined with in vivoCross-Linking
Christian Tagwerker,Karin Flick,Meng Cui,Cortnie Guerrero,Yimeng Dou,Bernhard Auer,Pierre Baldi,Lan Huang,Peter K. Kaiser +8 more
TL;DR: The HB tag is described, a new tandem affinity tag for two-step purification under denaturing conditions that allows effective mass spectrometric identification of in vivo cross-linked protein complexes, thereby expanding proteomic analyses to the description of weakly or transiently associated protein complexes.
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Development of a Novel Cross-linking Strategy for Fast and Accurate Identification of Cross-linked Peptides of Protein Complexes
Athit Kao,Chi-Li Chiu,Danielle Vellucci,Yingying Yang,Vishal R. Patel,Shenheng Guan,Arlo Randall,Pierre Baldi,Scott D. Rychnovsky,Lan Huang +9 more
TL;DR: This work developed a novel cross-linking strategy using a newly designed MS-cleavable cross-linker, disuccinimidyl sulfoxide (DSSO), which can find a broad range of applications in elucidating the structural topology of proteins and protein complexes.
Journal ArticleDOI
Patterns of Protein Synthesis and Tolerance of Anoxia in Root Tips of Maize Seedlings Acclimated to a Low-Oxygen Environment, and Identification of Proteins by Mass Spectrometry
William W.P. Chang,Lan Huang,Min Shen,Cecelia Webster,Alma L. Burlingame,Justin K. M. Roberts +5 more
TL;DR: It is shown that mass spectrometry can be effectively used to identify plant proteins arrayed by two-dimensional gel electrophoresis and the expression of proteins involved in a wide range of cellular functions, including previously reported anaerobic proteins, are described and discussed.