M
Marten P. Smidt
Researcher at University of Amsterdam
Publications - 130
Citations - 9055
Marten P. Smidt is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Dopaminergic & Substantia nigra. The author has an hindex of 43, co-authored 125 publications receiving 8267 citations. Previous affiliations of Marten P. Smidt include Utrecht University & University Medical Center Utrecht.
Papers
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Journal ArticleDOI
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.
Odila Saucedo-Cardenas,Juan D. Quintana-Hau,Wei-Dong Le,Marten P. Smidt,Joke J. Cox,Francesco J. De Mayo,J. Peter H. Burbach,Orla M. Conneely +7 more
TL;DR: It is demonstrated that Nurr1 functions at the later stages of dopamine cell development to drive differentiation of ventral mesencephalic late dopaminergic precursor neurons, and is essential for specifying commitment of mesENCEphalic precursors to the full dopamine phenotype.
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The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
TL;DR: Describing of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation.
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Insulin signaling in the central nervous system: learning to survive.
TL;DR: The hypothesis that the PI3K route forms a direct link between learning and memory and neuronal survival is provided, since it provides an explanation why insulin has beneficial effects on learning andMemory and how synaptic activity can prevent cellular degeneration.
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A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b.
TL;DR: The data suggest that at least two molecular cascades operate during the specification of the mesDA system, one specifying neurotransmitter phenotype and another essential for other aspects of mesDA neuron differentiation.
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A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
Marten P. Smidt,Hermien S. A. van Schaick,Christian Lanctôt,Jacques J. Tremblay,Joke J. Cox,Arno A. M. van der Kleij,Gerrit Wolterink,Jacques Drouin,J. Peter H. Burbach +8 more
TL;DR: A bicoid-related homeobox gene, Ptx3, a member of the Ptx-subfamily, that is uniquely expressed in mesencephalic dopaminergic neurons is identified and may be involved in developmental determination of this neuronal lineage.