Martin Everett

TL;DR: The data indicate that high-level fluoroquinolone resistance in E. coli involves the acquisition of mutations at multiple loci.

TL;DR: It is recommended that short courses of quinolones not be used in patients infected with NARST and that long-course ofloxacin therapy for uncomplicated typhoid should be avoided.

TL;DR: Clinical isolates and poultry isolates from Germany, The Netherlands and other regions of the UK collected before 1995 were examined for mutations in the quinolone resistance-determining region of gyrA by single-stranded conformational polymorphism analysis and direct sequencing of a 270 bp fragment of PCR-generated DNA.

TL;DR: The discovery of a novel MBL inhibitor, ANT431, that can potentiate the activity of meropenem (MEM) against a broad range of MBL-producing CRE and restore its efficacy against an Escherichia coli NDM-1-producing strain in a murine thigh infection model is reported.

TL;DR: This work describes the initial exploration of a novel chemical series of metallo-β-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.