Martin J. Cohn

TL;DR: The studies identify previously undescribed molecular dimorphisms between male and female limb buds and provide experimental evidence that the digit ratio is a lifelong signature of prenatal hormonal exposure and suggest that the 2D:4D ratio can serve as an indicator of disrupted endocrine signaling during early development, which may aid in the identification of fetal origins of adult diseases.

TL;DR: The results suggest that local production of an FGF may initiate limb development, and can be explained by the distribution of cells in the flank with potential polarizing activity.

TL;DR: It is shown that Hox gene expression domains are expanded along the body axis in python embryos, and that this can account for both the absence of forelimbs and the expansion of thoracic identity in the axial skeleton.

TL;DR: The identification of notochordal remnants in mice is the first step towards generating an in vivo model of chordoma and the development and characterization of a mouse model that can be used to fate map nucleus pulposus precursor cells in any mutant background will be useful for uncovering the cellular and molecular mechanisms of disk degeneration.

TL;DR: It is demonstrated that Shh from the urethral epithelium is required for outgrowth, patterning, and cell survival in the developing external genitalia in mice with a targeted deletion of Shh.