C
Chin Chiang
Researcher at Vanderbilt University
Publications - 64
Citations - 11284
Chin Chiang is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Sonic hedgehog & Hedgehog. The author has an hindex of 39, co-authored 63 publications receiving 10727 citations. Previous affiliations of Chin Chiang include University of South Alabama & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chin Chiang,Ying Litingtung,Eric Lee,Keith E. Young,Jeffrey L Corden,Heiner Westphal,Philip A. Beachy +6 more
TL;DR: Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
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Sonic hedgehog is essential to foregut development
TL;DR: Results indicate that Shh is required for the growth and differentiation of the oesophagus, trachea and lung, and suggest that mutations in SHH and its signalling components may be involved in foregut defects in humans.
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Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
TL;DR: It is proposed that the function of Shh and Gli3 in limb skeletal patterning is limited to refining autopodial morphology, imposing pentadactyl constraint on the limb's polydactyl potential, and organizing digit identity specification, by regulating the relative balance of Gli 3 transcriptional activator and repressor activities.
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Induction of midbrain dopaminergic neurons by Sonic hedgehog
Mary Hynes,Jeffery A. Porter,Chin Chiang,David C. Chang,Marc Tessier-Lavigne,Philip A. Beachy,Arnon Rosenthal +6 more
TL;DR: It is shown that the amino-terminal product of Sonic hedgehog autoproteolysis (SHH-N), an inductive signal expressed by floor plate cells, can induce dopaminergic neurons in vitro and provides the basis for a potential cell transplantation therapy for Parkinson's disease.
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Essential role for Sonic hedgehog during hair follicle morphogenesis.
Chin Chiang,Ryan Z. Swan,Marina Grachtchouk,Matthew Bolinger,Ying Litingtung,Erin K. Robertson,Michael K. Cooper,William Gaffield,Heiner Westphal,Philip A. Beachy,Andrzej A. Dlugosz +10 more
TL;DR: An obligatory role for the secreted morphogen Sonic hedgehog (Shh) during hair follicle development is reported, where it is required for normal advancement beyond the hair germ stage of development.