http://www.dietcan.net/docs/Polifenoles%20en%20alimentos%20y%20biodisponibilidad.pdf

Polyphenols: food sources and bioavailability

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Fish bioaccumulation and biomarkers in environmental risk assessment: a review

Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last four decades, an extensive body of literature regarding lipid peroxidation has shown its important role in cell biology and human health. Since the early 1970s, the total published research articles on the topic of lipid peroxidation was 98 (1970–1974) and has been increasing at almost 135-fold, by up to 13165 in last 4 years (2010–2013). New discoveries about the involvement in cellular physiology and pathology, as well as the control of lipid peroxidation, continue to emerge every day. Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting gene expression and promoting cell death. Finally, overviews of in vivo mammalian model systems used to study the lipid peroxidation process, and common pathological processes linked to MDA and 4-HNE are shown.

/pdf/lipid-peroxidation-production-metabolism-and-signaling-234bwmyps5.pdf

Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) have been described as dietary biomarkers of dairy-fat consumption with varying degrees of reliability between studies. It remains unclear how the total amount of dietary fat; one of the main confounding factors in these biomarker investigations, affects C15:0 and C17:0 circulating compositions independently to their relative intake. Additionally, it is unknown how changes in the dietary total-fat affects other fatty acids in circulation. Through two dietary studies with different total-fat levels but maintaining individual fatty acid compositions we were able to see how the dietary total-fat affects the fatty acids in circulation. We saw that there was a significant, proportionate, and robust decrease in the endogenous C15:0 levels with an increase in dietary total-fat. However, there was an increase in the circulating C17:0 compositions as the total-fat increased. To conclude, the dietary total-fat content and fat-type have a very complex influence on the relative compositions of circulating fatty acids, which are independent to the actual dietary fatty acid composition. Knowing how to manipulate circulating C15:0 and C17:0 composition is far-reaching in nutritional/pathological research as they highlight a dietary route to attenuate the development of metabolic disease (both by reducing risk and improving prognosis).

/pdf/the-dietary-total-fat-content-affects-the-in-vivo-blt4uenxpy.pdf

The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease

Binge ethanol exposure in mice represses expression of genes involved in osteoblast function and induces expression of genes involved in osteoclast differentiation independently of endogenous catalase.

In the decades, since the landmark characterization of cytochrome P450 by Omura and Sato in 1962, there has been an explosion of research into this group of heme proteins with the publication of th...

Preface to DMR special edition "cytochrome P450: new horizons".

fat-induced obesity gene expression and are protected against high Female mice lacking p47phox have altered adipose tissue

A "two-hit" model for NASH exists in which development of steatosis constitutes the "first hit" and sensitizes the liver to potential "second hits" resulting in NASH. Oxidative stress is possibly a...

Martin J. J. Ronis

Papers

The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease

Binge ethanol exposure in mice represses expression of genes involved in osteoblast function and induces expression of genes involved in osteoclast differentiation independently of endogenous catalase.

Preface to DMR special edition "cytochrome P450: new horizons".

fat-induced obesity gene expression and are protected against high Female mice lacking p47phox have altered adipose tissue

Effects of N -Acetylcysteine on Non-Alcoholic Steatohepatitis (NASH) in Rats Fed via Total Enteral Nutrition