M
Martin L. Breitman
Researcher at University of Toronto
Publications - 70
Citations - 15906
Martin L. Breitman is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 38, co-authored 70 publications receiving 15575 citations. Previous affiliations of Martin L. Breitman include University of Helsinki & Mount Sinai Hospital.
Papers
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Journal ArticleDOI
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Guo-Hua Fong,Janet Rossant,Janet Rossant,Marina Gertsenstein,Martin L. Breitman,Martin L. Breitman +5 more
TL;DR: It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
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Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
Arja Kaipainen,Jaana Korhonen,Tuija Mustonen,Victor W.M. van Hinsbergh,Guo-Hua Fang,Daniel J. Dumont,Martin L. Breitman,Kari Alitalo +7 more
TL;DR: The results suggest that FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues, and support the theory on the venous origin of lymphatic Vessels.
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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
Daniel J. Dumont,Gérard Gradwohl,Guo-Hua Fong,Mira C. Puri,Marina Gertsenstein,A. Auerbach,Martin L. Breitman +6 more
TL;DR: Observations demonstrate that the Tek signaling pathway plays a critical role in the differentiation, proliferation, and survival of endothelial cells in the mouse embryo.
Journal ArticleDOI
Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis
TL;DR: The results indicate that increased beta 1-6-linked branching of complex-type oligosaccharides on gp 130 may be an important feature of tumor progression related to increased metastatic potential.