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Martin L. Breitman

Researcher at University of Toronto

Publications -  70
Citations -  15906

Martin L. Breitman is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 38, co-authored 70 publications receiving 15575 citations. Previous affiliations of Martin L. Breitman include University of Helsinki & Mount Sinai Hospital.

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Journal ArticleDOI

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

Daniel J. Dumont, +7 more
- 30 Oct 1998 - 
TL;DR: It is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos, indicating an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
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flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

Terry P. Yamaguchi, +4 more
- 01 Jun 1993 - 
TL;DR: Flk-1 transcripts are expressed one full embryonic day earlier than the first tek transcripts, suggesting that these two RTKs appear to correlate with the specification and early differentiation of the endothelial cell lineage respectively, and therefore may play important roles in the establishment of this lineage.
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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

Daniel J. Dumont, +7 more
- 01 May 1995 - 
TL;DR: A possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role forVEGF during vascularization of the mouse embryo is suggested.
Journal Article

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors

Daniel J. Dumont, +4 more
- 01 Aug 1992 - 
TL;DR: In situ hybridization analysis of adult tissues, as well as sectioned and whole-mount embryos, showed that tek is specifically expressed in the endocardium, the leptomeninges and the endothelial lining of the vasculature from the earliest stages of their development.
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Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.

Stephen H. Hughes, +7 more
- 01 Dec 1978 - 
TL;DR: Assessment of DNA from 15 clones of avian sarcoma virus-transformed rat cells with restriction endonucleases and molecular hybridization techniques found that ASV DNA can be accommodated at many positions in cellular DNA, but the existence of preferred sites has not been excluded.