M
Martin Lenicek
Researcher at Charles University in Prague
Publications - 61
Citations - 1204
Martin Lenicek is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Bile acid & Population. The author has an hindex of 18, co-authored 55 publications receiving 1022 citations. Previous affiliations of Martin Lenicek include First Faculty of Medicine, Charles University in Prague & Maastricht University.
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Journal ArticleDOI
The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance
Tim C. M. A. Schreuder,Hendrik A. Marsman,Martin Lenicek,Jochem R. van Werven,Aart J. Nederveen,Peter L.M. Jansen,Frank G. Schaap +6 more
TL;DR: The hepatic response to FGF19 is impaired in NAFLD patients with insulin resistance (HOMA score > or =2.5), which may contribute to the dysregulation of lipid homeostasis inNAFLD.
Journal ArticleDOI
Differences in antitumor effects of various statins on human pancreatic cancer.
Helena Gbelcová,Martin Lenicek,Jaroslav Zelenka,Zdenek Knejzlik,Gabriela Dvoráková,M Zadinová,Pavla Pouckova,Michal Kudla,Peter Balaz,Tomáš Ruml,Tomáš Ruml,Libor Vítek +11 more
TL;DR: Substantial tumor‐suppressive effects of various statins on the progression of experimental pancreatic adenocarcinoma were demonstrated, with marked differences among individual statins, which support greatly the potential of statins for the chemoadjuvant treatment of pancreatic cancer.
Journal ArticleDOI
Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers.
Martin Lenicek,Dana Duricova,Viktor Komarek,Bronislava Gabrysova,Milan Lukas,Zdenek Smerhovsky,Libor Vítek,Libor Vítek +7 more
TL;DR: The most severe BAM occurs in CD patients after resection of the distal ileum, but BAM can occur in surgically untreated CD patients, regardless of disease localization.
Journal ArticleDOI
Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues.
Jaroslav Zelenka,Martin Lenicek,Lucie Muchová,Milan Jirsa,Michal Kudla,Peter Balaz,M Zadinová,J. D. Ostrow,Ronald J. Wong,Libor Vítek +9 more
TL;DR: This procedure yielded UCB levels directly comparable to published methods, and accurately determined very low tissue bilirubin concentrations (
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Determination of beta-defensin genomic copy number in different populations: a comparison of three methods.
Peder Fode,Cathrine Jespersgaard,Robert J. Hardwick,Helen Bogle,Michael Theisen,Daniel Dodoo,Martin Lenicek,Libor Vítek,Ana Rita Vieira,João Freitas,Paal Skytt Andersen,Edward J. Hollox +11 more
TL;DR: QPCR is very sensitive to quality of the template DNA, generating systematic biases that could produce false-positive or negative disease associations, but both triplex PRT and PPRT do not show this systematic bias, and type copy number within the correct range, although triplexPRT appears to be a more precise and accurate method to type beta-defensin copy number.