M
Martin A. Horstmann
Researcher at University of Hamburg
Publications - 97
Citations - 7644
Martin A. Horstmann is an academic researcher from University of Hamburg. The author has contributed to research in topics: Leukemia & Minimal residual disease. The author has an hindex of 35, co-authored 93 publications receiving 6865 citations. Previous affiliations of Martin A. Horstmann include Harvard University.
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A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study
Monique L. den Boer,Marjon van Slegtenhorst,Renee X. de Menezes,Renee X. de Menezes,Meyling Cheok,Jessica Buijs-Gladdines,Susan T C J M Peters,Laura J. C. M. van Zutven,H. Berna Beverloo,Peter J. van der Spek,Gaby Escherich,Martin A. Horstmann,Gritta Janka-Schaub,Willem A. Kamps,William E. Evans,Rob Pieters +15 more
TL;DR: A genome-wide study to improve prognostic classification of ALL in children revealed a new ALL subtype, the underlying genetic abnormalities of which were characterised by comparative genomic hybridisation-arrays and molecular cytogenetics.
Journal ArticleDOI
Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability
Gaël McGill,Martin A. Horstmann,Hans R. Widlund,Jinyan Du,Gabriela Motyckova,Emi K. Nishimura,Yi Ling Lin,Sridhar Ramaswamy,Sridhar Ramaswamy,William Avery,Han Fei Ding,Siobhán A. Jordan,Ian J. Jackson,Stanley J. Korsmeyer,Todd R. Golub,Todd R. Golub,David E. Fisher +16 more
TL;DR: Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2, which helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma.
Journal ArticleDOI
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
Min Wu,Timothy J. Hemesath,Timothy J. Hemesath,Clifford M. Takemoto,Martin A. Horstmann,Audrey G. Wells,E. Roydon Price,Daniel Z. Fisher,David E. Fisher +8 more
TL;DR: In this paper, c-kit signaling triggers two phosphorylation events on microphthalmia (Mi) which up-regulate transactivation potential yet simultaneously target Mi for ubiquitin-dependent proteolysis.
Journal ArticleDOI
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
Jinyan Du,Hans R. Widlund,Martin A. Horstmann,Sridhar Ramaswamy,Kenneth N. Ross,Wade E. Huber,Emi K. Nishimura,Todd R. Golub,Todd R. Golub,David E. Fisher +9 more
TL;DR: It is shown that, despite its ubiquitous expression, CDK2 exhibits tissue-specific regulation by the essential melanocyte lineage transcription factor MITF, and it may be a suitable drug target in melanoma.
Journal ArticleDOI
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Priscila Pini Zenatti,Daniel Dias Ribeiro,Wenqing Li,Linda Zuurbier,Milene Costa da Silva,Maddalena Paganin,Julia Tritapoe,Julie A. Hixon,André B. Silveira,Bruno A. Cardoso,Leonor M. Sarmento,Nádia C. Correia,María L. Toribio,Joerg Kobarg,Martin A. Horstmann,Rob Pieters,Silvia Regina Brandalise,Adolfo A. Ferrando,Jules P.P. Meijerink,Scott K. Durum,J. Andrés Yunes,João T. Barata +21 more
TL;DR: The findings indicate that IL7R mutational activation is involved in human T-cell leukemogenesis, paving the way for therapeutic targeting of IL-7R–mediated signaling in T-ALL.