Martin Pelletier

TL;DR: A syndrome characterized by recurrent fever, severe anemia, gastrointestinal symptoms, and a spectrum of immunologic and neurologic symptoms in five children from four unrelated families was observed.

TL;DR: A Caucasian family with an affected mother and 2 affected daughters presented with early onset Behcet–like disease, manifesting with arthralgia/arthritis, mouth and genital ulcers, and uveitis, which is significantly ameliorated with TNF-inhibitors.

TL;DR: The finding that methotrexate is able to induce AMPK activation in both human and mouse macrophages, and suppress pro-inflammatory cytokines in a manner dependent on AMPK activity raises the possibility that some anti-inflammatory effects of MTX are mediated by AMPK, and suggest that AMPK may be a target for the action of current ‘antimetabolite’ anti- inflammatory agents and a targets for the development of new anti- inflammation drugs.

TL;DR: In two models of allergic asthma, it is demonstrated that Tnfrsf25-/- mice have reduced disease severity accompanied by fewer IL-9 producing T cells in the lung, and TL1A enhances pathogenicity in Th9 transfer models of both uveitis and allergic asthma.